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Fig. 4 | Journal for ImmunoTherapy of Cancer

Fig. 4

From: Long-term survival without graft-versus-host-disease following infusion of allogeneic myeloma-specific Vβ T cell families

Fig. 4

Survival curves of myeloma bearing Balb/c recipient mice treated by irradiation, Auto-BMT and then allogeneic or autologous lymphocyte infusion. The presented results represent the average of two independent experiments. On day 10 and/or day 17 after Auto-BMT, recipient mice were injected i.v. with naïve or activated B10.D2 / Balb/c Vβ 2, 3 and 8.3 T cells. Recipient mice were sacrificed when severe GvHD symptoms, myeloma symptoms or apathy were present. Statistical significance between survival curves was determined using the Log-Rank test. MM-Auto-BMT versus MM-Auto-BMT + Auto activated vβ 2, 3, 8.3 (× 1), *p < 0.0001; MM-Auto-BMT versus MM-Auto-BMT + Allo naive vβ 2, 3, 8.3 (× 1), **p = 0.0001

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