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Fig. 6 | Journal for ImmunoTherapy of Cancer

Fig. 6

From: Long-term survival without graft-versus-host-disease following infusion of allogeneic myeloma-specific Vβ T cell families

Fig. 6

Histologic changes in skin. Comparive histology of skin tissue collected from the interscapular region of mice who received auto-BMT alone, IL-2/anti-CD3/anti-CD28 activated B10.D2 Vβ 2, 3 and 8.3 T cells, naive B10.D2 Vβ 2, 3 and 8.3 T cells (× 2) or unselected naive B10.D2 spleenocytes. H&E reveals normal epidermis in the samples of mice who received auto-BMT alone (a), IL-2/anti-CD3/anti-CD28 activated B10.D2 Vβ 2, 3 (b) and 8.3 T cells and naive B10.D2 Vβ 2, 3 and 8.3 T cells (× 2) (c), whereas there is decrease in follicular units, increased collagen density with increased cellularity (fibrosis) in the sample of mice who received unselected naive B10.D2 spleenocytes (d). Original magnification × 10. GvHD disease score (based on weight loss, hunched back posture, general activity, alopecia and skin fibrosis, on a scale of 0–10), was calculated

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