Fig. 4

Serum cytokine profile of mice injected with IL-15-secreting leukemia cells. a Serum was taken eight days post ip-administration of leukemia cells. A control group of naïve mice was included. Results shown are mean + SEM calculated from 4 individual mice/group from one representative experiment performed at least twice. Corresponding p values can be found next to the graph. b Only IL-15sol could be detected in mouse serum using the 31-plex analysis (EveTechnologies, Calgary). We repeated the analysis of IL-15 in mouse serum using our ELISA systems to detect IL-15sol c as well as IL-15Rc d. Both c and d show a time course where mice were bled prior to injection and then on days 5, 8, 16 and 30 post-injection of IL-15 secreting leukemia cells