Fig. 6

T-cells of mice injected with IL-15Rc secreting leukemia cells express significantly higher levels of exhaustion and activation markers 50+ days post-ip-injection. a PD-1; b CD4⁺/CD8⁺; c CD25⁺; d CD44⁺; e GrzB⁺ and f NK1.1⁺GrzB⁺ cells. Each data point represents 1 mouse. Numbers shown are total cell numbers calculated based on the absolute cell numbers obtained by peritoneal lavage. Naïve mice were included to obtain baseline levels and were included on the graph on the day they were analyzed. Experiments have been performed four times with 1–2 mice sacrificed per group, and results were pooled. For statistical analysis mean values were compared within groups using 2-way ANOVA with Tukey’s post-test. P-values are denoted with asterisks (* = p = < 0.05,** = p = < 0.01, *** = p = < 0.001, **** = p = < 0.0001)