Fig. 3From: Calreticulin exposure correlates with robust adaptive antitumor immunity and favorable prognosis in ovarian carcinoma patientsTranscriptional signatures of the tumor microenvironment of CALRHi versus CALRLo HGSCs. a Hierarchical clustering of significantly upregulated and downregulated genes in 77 CALRHi versus 77 CALRLo HGSC patients from the TCGA public database (302 patients were divided into 4 groups using quartile stratification, only lower (no = 77) and upper (no = 77) quartile is presented). b Relative expression levels of genes linked to T cells activation, TH1 polarization, T cell migration, cytotoxicity, antigen processing, activated DCs (aDCs), B cells and NK cells in 77 CALRHi versus 77 CALRLo TCGA HGSCs (302 patients were divided into 4 groups using quartile stratification, only lower (no = 77) and upper (no = 77) quartile is presented). Box plots: lower quartile, median, upper quartile; whiskers, minimum, maximum. c Relative abundance of CD8+ T cells and cytotoxic effector functions across 77 CALRHi and 77 CALRLo TCGA HGSCs (302 patients were divided into 4 groups using quartile stratification, only lower (no = 77) and upper (no = 77) quartile is presented). Box plots: lower quartile, median, upper quartile; whiskers, minimum, maximumBack to article page