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Table 2 Multinomial logistic regression predicting treatment in a low vs. high immunotherapy prescribing hospital (accounting for the middle quintiles)

From: Adoption of immunotherapy in the community for patients diagnosed with metastatic melanoma

 

Relative risk ratio

95% Confidence Interval

p-value

Age

  ≤ 30

Ref.

  

 41–50

1.04

0.20–5.32

0.964

 51–60

0.84

0.17–4.18

0.834

 61–70

1.28

0.25–6.49

0.766

 71–80

1.19

0.25–5.68

0.831

 81–90

2.24

0.46–10.9

0.318

Gender

 male

Ref.

  

 female

0.86

0.62–1.18

0.346

Race

 White

Ref.

  

 Black

0.36

0.11–1.14

0.081

 Other/unknown

1.97

0.71–5.46

0.193

Year of Diagnosis

 2011

Ref.

  

 2012

1.28

0.82–2.01

0.287

 2013

1.08

0.69–1.70

0.728

 2014

1.40

0.89–2.22

0.147

 2015

1.83

1.17–2.87

0.008

Charlson Deyo Index

 0

Ref.

  

 1

1.11

0.73–1.71

0.623

 2

1.30

0.50–2.21

0.888

  > =3

1.93

0.77–4.87

0.162

Primary Site

 Head and Neck

Ref.

  

 trunk

1.41

0.74–2.71

0.294

 extremities

1.30

0.72–2.33

0.379

 overlapping

1.25

0.60–2.63

0.550

Histology

 Melanoma, NOS

Ref.

  

 nodular

0.78

0.44–1.39

0.396

 Lentigo

0.35

0.04–3.44

0.369

 superficial

0.87

0.38–2.00

0.749

 Acral

0.47

0.07–3.01

0.424

 other

0.91

0.43–1.93

0.798

Metastatic stage

 M1, NOS

Ref.

  

 M1a

0.42

0.15–1.17

0.097

 M1b, lung

0.39

0.14–1.10

0.075

 M1c, visceral

0.22

0.08–0.62

0.004

 Brain involvement

0.44

0.15–1.23

0.116

Ulceration

 No ulceration

Ref.

  

 ulceration

0.88

0.54–1.46

0.631

 unknown

0.63

0.35–1.15

0.132

Breslow (continuous)

1.00

1.00–1.00

0.141

Insurance

 Private

Ref.

  

 Medicare

1.13

0.74–1.71

0.576

 Medicaid

2.10

1.12–3.92

0.020

 Other

1.11

0.34–3.63

0.850

 No insurance

2.44

1.28–4.67

0.007

 unknown

0.28

0.07–1.16

0.080

Income*

  ≥ $63,000

Ref.

  

 $48,999–$62,999

1.25

0.65–2.40

0.509

 $38,000–$47,999

0.93

0.36–2.41

0.887

  < $38,000

1.71

0.57–5.14

0.339

 unknown

0.29

0.02–3.54

0.333

Education*,**

  ≥ 21%

Ref.

  

 13%-20,9%

1.14

0.55–2.37

0.730

 7–12,9%

0.97

0.40–2.33

0.943

  < 7%

0.61

0.21–1.76

0.360

 unknown

6.10

0.38–98.55

0.203

Distance

  < 12.5mi

Ref.

  

 12.5-50mi

0.58

0.38–0.88

0.011

  ≥ 50mi

0.14

0.07–0.30

< 0.001

 unknown

0.38

0.07–2.23

0.285

Facility Location

 Northeast

Ref.

  

 South

5.06

0.98–26.03

0.052

 Midwest

0.97

0.15–6.06

0.973

 West

1.81

0.35–9.30

0.475

Facilitytype

 Academic

Ref.

  

 CCCP

5.18

1.69–15.88

0.004

 INCP

6.60

1.06–41.14

0.043

County

 Metro

Ref.

  

 Urban

2.58

1.34–4.96

0.005

 Rural

1.93

0.32–11.74

0.476

 unknown

1.25

0.45–3.45

0.671

  1. Abbreviations: NOS = not otherwise specified, mi = miles; CCCP = comprehensive community cancer program; INCP = integrated network cancer program
  2. Significant p-values in italic
  3. *ZIP-code level variable
  4. **Percentage of residents in home county with no high school degree from 2012 American County Survey Data
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