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Table 1 Univariate and multivariate analysis of factors associated with overall survival and relapse-free survival

From: EZH2 negatively regulates PD-L1 expression in hepatocellular carcinoma

VariablesOSRFS
UnivariateMultivariateUnivariateMultivariate
pHR95% CIppHR95% CIp
Gender (female/male)0.396   0.528   
Age,y (> 50/≤50)0.711   0.346   
HBsAg (present/absent)0.759   0.107   
AFP, ng/ml (> 25/≤25)<  0.00011.5881.122–2.2490.0090.0011.2580.963–1.6430.092
Tumor size, cm (> 5/≤5)0.0110.9050.645–1.2710.5650.0400.9280.706–1.2190.590
Tumor multiplicity (multiple/solitary)<  0.00011.4681.006–2.1420.046<  0.00011.5181.094–2.1070.012
Vascular invasion (present/absent)<  0.00013.3892.205–5.209<  0.0001<  0.00012.2571.547–3.293<  0.0001
TNM stage (III + IV/I + II)<  0.00011.6321.086–2.4530.018<  0.00011.2940.914–1.8310.146
Differentiation (III + IV/I + II)0.55   0.700   
Combination of EZH2 and PD-L10.00041.2281.050–1.4360.0100.00021.2541.100–1.4300.001
  1. Variables associated with overall survival or relapse-free survival by univariate analysis were adopted as covariates in multivariate analysis and entered into the equation by the forward selection based on likelihood ratio test
  2. Abbreviations: OS Overall survival, RFS Relapse-free survival, HR Hazard ratio, CI Confidence interval