Skip to main content
Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Tumor microenvironment dictates regulatory T cell phenotype: Upregulated immune checkpoints reinforce suppressive function

Fig. 2

PD-1 expression in Foxp3+ Treg in different tissue types of patients with cancer. a Representative plots of CD25 and Foxp3 expression (left) and proportion of Foxp3+ T cells (right) among CD4+ T cells. b Representative plots of PD-1 and Foxp3 expression (left) and proportion of PD-1 and Foxp3 co-expressing cells among total CD4+ T cells (right). c Summary of PD-1-positive fraction of Foxp3+ Tconv (left) and Foxp3 Treg (right) cell populations among CD4+ T cells. Peripheral blood lymphocytes (PBLs), effusion-infiltrating lymphocytes (EILs), and tumor-infiltrating lymphocytes (TILs) were isolated from healthy control donors (PBL, n = 16) and patients with cancer (PBL, n = 28; EIL, n = 76; TIL, n = 31). Lines in the scatterplot represent the mean values. ns, not significant; **P < 0.01, ***P < 0.001 (Mann-Whitney test)

Back to article page