Time before and after CAR T cell therapy | Date | Key events |
---|---|---|
−5 years | 2014/7 | Diagnosis of DLBCL |
−5 to −0.5 years | 2014/7 to 2018/1 | 8 cycles of R-CHOP and sustained remission |
−1 year | 2017/7 | Discontinuation of entecavir |
−6 months | 2018/1 | Relapse/reintroduction of entecavir |
−4 days to −2 days | 2018/6/29 to 2018/7/1 | Standard lymphodepleting chemotherapy regimen |
0 days | 2018/7/3 | Start of CART therapy |
0 days to + 3 days | 2018/7/3 to 2018/7/6 | Sequential infusion of anti-CD 19 and anti-CD22 CAR T cell therapy |
+ 4 weeks | 2018/8/4 | Discontinuation of entecavir |
+ 9 weeks | 2018/9/4 | Activation of hepatitis B |
+ 3.3 months | 2018/10/12 | Death |