Fig. 2

Cycle 1 and steady-state (cycle 10) exposure metrics by age group: (a) C_max, (b) C_min, and (c) AUC. Expected interquartile range (IQR) from simulated distributions (n = 1000) based on reported geometric means and %CVs. The box-plots indicate the median and IQR (25th to 75th percentile). The whiskers indicate 1.5 times the IQR. Abbreviations: AUC area under the curve, C_min minimum concentration, C_max maximum concentration