|
Covariate
|
Infants < 2 years n = 2
|
Children 2 to < 12 years n = 29
|
Adolescents 12 to < 18 years n = 38
|
Young adults ≥ 18 years n = 18
|
|---|
|
n (%)
|
Median (min–max)
|
n (%)
|
Median (min–max)
|
n (%)
|
Median (min–max)
|
n (%)
|
Median (min–max)
|
|---|
|
Age, years
|
2
|
1 (0.6–1.5)
|
29
|
7 (2–11)
|
38
|
15 (12–17)
|
18
|
22 (18–29)
|
|
Body weight, kg
|
2
|
9.1 (8.7–9.5)
|
29
|
22.5 (12.0–74.4)
|
38
|
51.1 (28.2–105)
|
18
|
61.0 (46.2–154)
|
|
Albumin, g/L
|
2
|
33 (30–35)
|
28a
|
41 (23–46)
|
38
|
41 (29–49)
|
18
|
39 (27–47)
|
|
Tumor burden, mm
|
2
|
59 (35–83)
|
23b
|
55 (15–301)
|
28d
|
78 (11–208)
|
15e
|
120 (10–258)
|
|
Female
|
1 (50)
|
–
|
14 (48)
|
–
|
16 (42)
|
–
|
9 (50)
|
–
|
|
ADA positive
|
0 (0)a
|
–
|
5 (17)c
|
–
|
4 (11)e
|
–
|
2 (11)a
|
–
|
|
No. of tumor types present
|
2
|
1
|
29
|
12
|
38
|
15
|
18
|
10
|
|
Lansky/Karnofsky PS
|
2
|
90 (90–90)
|
29
|
100 (60–100)
|
38
|
90 (70–100)
|
18
|
95 (70–100)
|
- Abbreviations: ADA Anti-drug antibodies, PS Performance status
- an = 1, bn = 6, cn = 5, dn = 10, en = 3 missing covariates were imputed to the median value
