Table 1 Characteristics in cohorts A and B according to bone involvement
From: Bone metastases and immunotherapy in patients with advanced non-small-cell lung cancer
Characteristic | Cohort A | Cohort B | ||||
|---|---|---|---|---|---|---|
Non-squamous BoM+ (N/%) | Non-squamous BoM- (N/%) | p | Squamous BoM+ (N/%) | Squamous BoM- (N/%) | p | |
Total patients | 626 (39) | 962 (61) | 120 (32) | 251 (68) | ||
Median age (year/range) | 65 (29–89) | 67 (27–87) | 0.001 | 67 (31–83) | 68 (31–91) | 0.06 |
Patients ≥75 years | 67 (11) | 165 (17) | < 0.0001 | 18 (15) | 52 (21) | 0.19 |
Gender | ||||||
• Male | 401 (64) | 628 (65) | 96 (80) | 202 (81) | 0.91 | |
• Female | 225 (36) | 334 (35) | 0.62 | 24 (20) | 49 (19) | |
ECOG PS | ||||||
• 0 | 213 (34) | 435 (45) | < 0.0001 | 36 (30) | 98 (39) | 0.25 |
• 1 | 354 (56) | 461 (48) | 77 (64) | 138 (55) | ||
• 2 | 57 (9) | 51 (5) | 7 (6) | 15 (6) | ||
• Unk | 2 (1) | 15 (2) | – | – | ||
Metastatic site | ||||||
• liver | 178 (28) | 149 (16) | < 0.00001 | 25 (21) | 38 (15) | 0.14 |
• brain | 191 (30) | 218 (23) | 0.001 | 16 (13) | 21 (8) | 0.17 |
Previous therapies | ||||||
• 1 | 256 (41) | 359 (37) | 0.07 | 54 (44) | 108 (43) | 0.67 |
• 2 | 176 (28) | 281 (29) | 37 (31) | 83 (33) | ||
• 3 | 118 (19) | 162 (17) | 20 (17) | 48 (19) | ||
• > 3 | 74 (12) | 154 (16) | 9 (8) | 12 (5) | ||
Smoking status | ||||||
• Never smoker | 134 (21) | 171 (18) | 0.06 | 13 (11) | 18 (7) | 0.14 |
• Former smoker | 308 (49) | 457 (48) | 69 (57) | 156 (62) | ||
• Active smoker | 134 (21) | 226 (23) | 23 (19) | 60 (24) | ||
• Unk | 50 (8) | 108 (11) | 15 (13) | 17 (7) | ||
EGFR status | ||||||
• Mutated | 47 (8) | 55 (6) | 0.10 | |||
• Wild-type | 514 (82) | 779 (81) | ||||
• Unk | 65 (10) | 128 (13) | ||||
KRAS status | ||||||
• Mutated | 91 (15) | 115 (12) | 0.23 | |||
• Wild-type | 132 (21) | 192 (20) | ||||
• Unk | 403 (64) | 655 (68) | ||||
BRAF status | ||||||
• Mutated | 5 (1) | 6 (1) | 0.54 | |||
• Wild-type | 85 (14) | 114 (12) | ||||
• Unk | 536 (85) | 842 (87) | ||||
ALK status | ||||||
• Mutated | 5 (1) | 11 (1) | 0.51 | |||
• Wild-type | 407 (65) | 645 (67) | ||||
• Unk | 214 (34) | 306 (32) | ||||
ROS1 status | ||||||
• Mutated | 3 (1) | 1 (1) | 0.29 | |||
• Wild-type | 142 (23) | 207 (21) | ||||
• Unk | 481 (76) | 754 (78) | ||||