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Table 3 Univariate and multivariate analyses for OS in cohorts A and B combined

From: Bone metastases and immunotherapy in patients with advanced non-small-cell lung cancer

 Cohort ACohort B
FactorsUnivariate analysis
HR (95% C.I.)
pMultivariate analysis
HR (95% C.I.)
pUnivariate analysis
HR (95% C.I.)
pMultivariate analysis
HR (95% C.I.)
p
Age (≥ 65 vs ≤ 65)0.9 (0.80–1.04)0.181.13 (0.86–1.47)0.38
Gender
 (male vs female)1.03 (0.89–1.18)0.731.20 (0.87–1.67)0.27
ECOG PS
 1 vs 01.59 (1.37–1.83)< 0.00011.45 (1.24–1.69)< 0.00011.59 (1.20–2.11)0.0011.51 (1.14–2.00)0.04
 2 vs 03.47 (2.71–4.45)< 0.00013.09 (2.38–4.02)< 0.00012.53 (1.54–4.17)< 0.00012.46 (1.49–4.05)< 0.0001
Smoking habits
 Current/former vs never0.85 (0.72–1.00)0.051.27 (0.79–2.07)0.32
Brain mets
(yes vs no)
1.24 (1.06–1.43)0.0061.07 (0.70–1.63)0.75
Liver mets
(yes vs no)
1.84 (1.58–2.15)< 0.00011.64 (1.39–1.93)< 0.00011.58 (1.16–2.15)0.0041.43 (1.01–1.95)0.03
Bone mets
(yes vs no)
1.67 (1.46–1.91)< 0.00011.50 (1.30–1.73)< 0.00011.90 (1.47–2.47)< 0.00011.78 (1.37–2.31)< 0.0001
Previous CT Lines
 2 vs 10.87 (0.73–1.03)0.100.91 (0.61–1.22)0.54
  > 2 vs 11.03 (0.88–1.210.67  0.73 (0.53–1.02)0.06