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Fig. 1 | Journal for ImmunoTherapy of Cancer

Fig. 1

From: Longitudinal immune characterization of syngeneic tumor models to enable model selection for immune oncology drug discovery

Fig. 1

Impact of α-mPD-L1+ α -mCTLA-4 treatment on tumor growth in syngeneic models. Line graphs show tumor volumes from (a) Balb/c CT-26 tumor bearing mice treated with isotype control or (b) anti-mPD-L1 + anti-mCTLA-4 combination treatment; (c) C57Bl/6 MC38 tumor bearing mice treated with Isotype Control or (d) anti-mPD-L1 + anti-mCTLA-4 combination treatment; (e) Balb/c 4T1 tumor bearing mice treated with isotype control or (f) anti-mPD-L1 + anti-mCTLA-4 combination treatment. Vertical dotted lines indicate the period of dosing. n=12 per group. Number of responders (those surviving longer than the last vehicle treated) in each model is indicated on each plot

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