Table 1 Parameter values for the cancer-immune ecology model, estimated from experimental data of BCL 1 lymphoma in the spleen of chimeric mice (see [20])
From: Genetic instability as a driver for immune surveillance
Parameter | Meaning | Kuznetsov et al. (1994) estimate |
|---|---|---|
r | Cancer cell replication rate | 0.18day −1 |
K | Tumor carrying capacity | 2×109cells |
δc | Immune-mediated cancer cell death rate | 1.101×10−7day−1cells−1 |
δE | Cancer-mediated immune cell death rate | 3.422×10−10day−1cells−1 |
m | Rate of T cell migration towards tumor site | 1.3×104cells day −1 |
g | Tumor size limit for effective T cell infiltration | 2.019×107cells |
ρ | Rate of cancer cell recognition by the immune system | 0.1245day −1 |
d | Intrinsic T cell death rate | 0.0412day −1 |