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Table 3 Multivariate Cox regression analysis of clinical parameters and serum biomarkers

From: Combined immune checkpoint blockade for metastatic uveal melanoma: a retrospective, multi-center study

ParameterCategoryHR (95% CI)P-value
ECOG statusn.a. (ordinal)3.19 (1.36–7.47)0.007*
LDHnormal10.428
elevated (>ULN)1.83 (0.41–8.08) 
CRPnormal10.534
elevated (>ULN)1.73 (0.31–9.74) 
Bone metastasisno10.331
yes2.02 (0.49–8.27) 
  1. Four parameters were included in the multivariate Cox regression analysis. Of these factors, ECOG status was significantly associated with overall survival in this model. Abbreviations: CI Confidence interval, n.a. not applicable, ULN Institutional upper limit of normal, LDH Lactate dehydrogenase, CRP C-reactive protein; *p<0.05.