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Table 1 Sequence of systemic therapies administered since diagnosis of cutaneous T-cell lymphoma/ Sézary Syndrome

From: Rapid and sustained response to immune checkpoint inhibition in cutaneous squamous cell carcinoma after allogenic hematopoietic cell transplant for sézary syndrome

Prior therapy for CTCL/SS

Sequence and Duration

Photochemotherapy (PUVA)

First Line of Therapy

8 months (2009)

Photopheresis

Second Line of Therapy

31 months (2009–2012)

Romidepsin

Third Line of Therapy

48 months (2010–2014)

Pegylated liposomal doxorubicin

Fourth Line of Therapy

3 months (2014)

Gemcitabine

Fifth Line of Therapy

1 month (2014)

Alemtuzumab

Sixth Line of Therapy

2 months (2015)

Mogamulizumab

Seventh Line of Therapy

1 month (2015)

Total skin electron beam therapy

Eighth Line of Therapy

3 months (2016)

Bexarotene

Ninth Line of Therapy

2 months (2016)

Pralatrexate

Tenth Line of Therapy

2 months (2016)

ICE (Ifosfamide, Carboplatin, Etoposide)

Eleventh Line of Therapy

3 months (2016–2017)

Sibling allogenic stem cell transplantation

Twelfth Line of Therapy

(2017)