Fig. 1
From: Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors
Mechanisms of Response Dependent and Response Independent Autoimmune Toxicity from Immune Checkpoint Inhibitors. On top left is a depiction of myocardial cells expressing shared antigens with the tumor which leads to autoimmunity. On bottom left is a depiction of IL-6 production from T-cell activation resulting in attack on enterocytes. On top right is a depiction of encephalitis as a result of an anti-viral response being unleashed by ICI treatment. On bottom right is a depiction of endogenous CTLA-4 expression on the pituitary gland leading to T-cell attack after anti-CTLA-4 treatment. Abbreviations: APC, antigen presenting cell; TCR, T-cell receptor; CTLA-4, cytotoxic T-lymphocyte-associated protein 4; PD-1, programmed cell death protein 1; PD-L1, programmed death-ligand 1; Ag, antigen; MHC, major histocomptability complex; Pit, pituitary gland