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Fig. 3 | Journal for ImmunoTherapy of Cancer

Fig. 3

From: Sarcosine promotes trafficking of dendritic cells and improves efficacy of anti-tumor dendritic cell vaccines via CXC chemokine family signaling

Fig. 3

The immunological response of sarcosine treated DCs in non-tumor bearing mice and the efficacy of sarcosine treated DCs in tumor bearing mice. a Splenocytes were analyzed by flow cytometry after tumor bearing mice received DC vaccines. CD8 T cells increased in mice treated with sarcosine treated DCs. Mean 39.72% ± 0.86 for control and 45.04% ± 0.64 for sarcosine treated DCs. (p < 0.0011, unpaired t test, n=5). b Antigen specific CD8 T cells in the spleens also increased in sarcosine treated DC group. Mean 1.22 ± 0.16% for control and 2.63 ± 0.50% for sarcosine treated DCs. (p < 0.0270, unpaired t test, n=5). c Tregs were similar between groups. Mean 17.34% ± 1.62 for control and 14.62% ± 1.19 for sarcosine treated DCs. (p < 0.2124, unpaired t test, n=5). d B16F10-OVA tumor bearing animals were treated with sarcosine treated DCs versus control DCs. Sarcosine treated DCs reduced tumor growth significantly. Mean tumor volume 1491 mm3 for control, 905 mm3 for DC and 338.8 mm3 for sarcosine treated DCs at day 26. (p=<0.0001, 2 way ANOVA, n=10)

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