Skip to main content
Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Sarcosine promotes trafficking of dendritic cells and improves efficacy of anti-tumor dendritic cell vaccines via CXC chemokine family signaling

Fig. 5

Sarcosine and cellular metabolism. a Nanostring ™ analysis of murine myeloid-derived DCs treated with sarcosine were compared to control DCs. CXCR2 (p<0.01) and CXCL3 (p<0.05) were highly expressed in the sarcosine-treated group. b Nanostring metabolic pathway analysis demonstrated overexpression of Ptgs1 (Cyclooxygenase 1) (p<0.1) and Pik3cg (p<0.5) genes. c The presence of reactive oxidative species (ROS) was evaluated based on fluorescence intensity in murine BM-DC. Sarcosine increased ROS in BM-DCs compare to untreated BM-DCs. Mean fluorescence intensity was 12.14 for untreated DCs, 44.05 for sarcosine treated DCs and 43.23 for positive control (p <0.0001, one-way ANOVA, n=5)

Back to article page