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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Soluble immune checkpoint-related proteins as predictors of tumor recurrence, survival, and T cell phenotypes in clear cell renal cell carcinoma patients

Fig. 2

Risk score of soluble immune checkpoints as predictor of ccRCC survival and its correlation with T cell functions in primary tumors. a Risk score derived from 2 soluble immune checkpoint proteins (sBTLA, sTIM3) predicted overall survival (OS). Risk score green line represented low-risk group, and risk score blue dot line was medium-risk group, and red dot line was high-risk group. Risk groups were tertiled by the risk score. b Scatter plot of sLAG3 (blue) and sCD28 (red) levels (y-axis) against CYT score (x-axis). c-d Scatter plot of LAG3 (red) and PDCD1 (blue) expression (y-axis) against CD8A gene expression (x-axis) in ccRCC tumors from (C) MDACC cohort (n = 47) and (D) TCGA cohort (n = 533)

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