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Table 2 Soluble immune checkpoint proteins and association with clinical outcomes of ccRCC patients

From: Soluble immune checkpoint-related proteins as predictors of tumor recurrence, survival, and T cell phenotypes in clear cell renal cell carcinoma patients

Protein namesAdvanced diseaseRecurrenceSurvival
High vs lowaAdjusted OR (95%CI)bP valueAdjusted HR (95%CI)cP valueAdjusted HR (95%CI)cP value
sTIM31 (reference) 1 (reference) 1 (reference) 
2.61 (1.07–6.40)0.041.65 (0.61–4.40)0.323.12 (1.44–6.75)3.94E-03#
sCD271 (reference) 1 (reference) 1 (reference) 
0.62 (0.34–1.16)0.141.44 (0.68–3.03)0.342.80 (1.17–6.67)0.02
sCD281 (reference) 1 (reference) 1 (reference) 
0.45 (0.18–1.16)0.102.30 (0.96–5.51)0.062.71 (1.13–6.47)0.02
sCTLA41 (reference) 1 (reference) 1 (reference) 
1.75 (0.91–3.40)0.102.13 (1.06–4.28)0.031.12 (0.51–2.44)0.78
sIDO1 (reference) 1 (reference) 1 (reference) 
1.25 (0.62–2.54)0.540.48 (0.19–1.23)0.130.49 (0.06–3.99)0.51
sLAG31 (reference) 1 (reference) 1 (reference) 
3.36 (1.55–7.27)2.13E-03#1.38 (0.32–6.00)0.662.21 (0.95–5.15)0.07
sBTLA1 (reference) 1 (reference) 1 (reference) 
0.66 (0.33–1.33)0.250.61 (0.30–1.27)0.196.02 (2.00–18.1)1.39E-03#
sPDL11 (reference) 1 (reference) 1 (reference) 
4.59 (0.91–23.3)0.071.51 (0.89–2.56)0.121.57 (0.70–3.49)0.27
sPDL21 (reference) 1 (reference) 1 (reference) 
0.53 (0.18–1.57)0.252.51 (1.46–4.34)9.33E-04#2.39 (0.97–5.88)0.06
  1. Abbreviations: OR Odds ratio, HR Hazard ratio, CI Confidence interval. Significant values in bold font
  2. aHigh- and low-level groups dichotomized by the logistic regression spline model [12]
  3. bAdjusted by age, gender, smoking, BMI, diabetes, and hypertension
  4. cAdjusted by age, gender, smoking, BMI, diabetes, hypertension, histology, grade, stage and treatment
  5. # Significant after Bonferroni adjustment for multiple testing