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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Blocking CD47 efficiently potentiated therapeutic effects of anti-angiogenic therapy in non-small cell lung cancer

Fig. 2

Anti-angiogenic treatment activated TNF-α/NF-κB1 pathway in NSCLC cells. a Quantitation of CA9 and CD47 in NSCLC xenograft tumors treated with IgG1-Fc or angiogenesis inhibitor. b Quantitation of NF-κB1 and CD47 in tumors treated with IgG1-Fc or angiogenesis inhibitors. c and d Immunofluorescence staining of NF-κB1 and CD47 in A549 (c) and NCI-H1975 (d) xenograft tumor tissues. e and f Quantitative polymerase chain reaction (qPCR) analysis of TNF-α in FACS-sorted TCs, ECs and ICs from A549 (e) and NCI-H1975 (f) xenograft tumors. (** P < 0.01, N = 5 per group, each point indicated an independent value)

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