Fig. 5

Targeting CD47 elicited macrophage cytotoxicity and phagocytosis against relapsed NSCLC cells. a SIRPα-Fc elicited macrophage cytotoxicity against relapsing A549, NCI-H1975 and LLC cells under various effector: target cell ratio. b SIRPα-Fc increased macrophage phagocytosis of relapsing A549, NCI-H1975 and LLC cells. (Each point repeated a value from one independent experiment and data were shown as mean ± SD). c A549 or LLC tumor models were established. CD68 staining was employed to detect macrophage depletion. d Tumor volume and tumor weight (e and f) were measured and shown as mean ± SD. (N = 5 per group). NS: no significance; * P < 0.05, ** P < 0.01