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Table 1 Univariate and Multivariate analysis in the training cohort (n = 358)

From: PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma

VariablesUnivariate analysisMultivariate analysis
ABC
PHR (95%CI)PHR (95%CI)PHR (95%CI)P
Liver cirrhosis (no vs. yes)0.0300.816 (0.418–1.591)0.5500.816 (0.418–1.591)0.5500.871 (0.449–1.688)0.682
Serum ALT, U/L (≤ 40 vs. > 40)0.0010.534 (0.335–0.848)0.0080.534 (0.335–0.848)0.0080.552 (0.346–0.879)0.012
γ-GT, U/L (> 75 vs. ≤ 75)0.0231.295 (0.883–1.898)0.1851.295 (0.883–1.898)0.1851.257 (0.856–1.846)0.243
Tumor size (cm) (>  5 vs. ≤ 5)< 0.00011.984 (1.461–2.696)< 0.00011.984 (1.461–2.696)< 0.00012.006 (1.474–2.729)< 0.0001
Tumor number (multiple vs. single)0.0011.451 (1.006–2.092)0.0461.451 (1.006–2.092)0.0461.432 (0.993–2.064)0.054
Vascular invasion (yes vs. no)< 0.00011.701 (1.254–2.307)0.0011.701 (1.254–2.307)0.0011.695 (1.250–2.300)0.001
TNM stage (I vs. II-III)< 0.00010.799 (0.388–1.647)0.5430.799 (0.388–1.647)0.5430.831 (0.404–1.710)0.615
CD8+PD1Int/ CD8+PD1+ (high vs. low)0.0050.686 (0.497–0.947)0.022    
CD8+PD1Hi/ CD8+PD1+
(high vs. low)
0.005  1.458 (1.056–2.013)0.022  
CD8+TIM3+ PD1Hi/ CD8+PD1+ (high vs. low)0.002    1.476 (1.085–2.008)0.013
  1. Abbreviations: ALT Alanine transaminase, γ-GT Gamma-Glutamyl-transpeptidase, TNM Tumor-nodes-metastases, HR Hazard ratio, CI Confidential interval. A:CD8+PD1Int/ CD8+PD1+; B:CD8+PD1Hi/ CD8+PD1+; C:CD8+TIM3+PD1Hi/ CD8+PD1+. Multivariate analysis was performed by the Cox multivariate proportional hazard regression model with stepwise manner