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Table 1 Univariate and Multivariate analysis in the training cohort (n = 358)

From: PD1Hi CD8+ T cells correlate with exhausted signature and poor clinical outcome in hepatocellular carcinoma

Variables Univariate analysis Multivariate analysis
A B C
P HR (95%CI) P HR (95%CI) P HR (95%CI) P
Liver cirrhosis (no vs. yes) 0.030 0.816 (0.418–1.591) 0.550 0.816 (0.418–1.591) 0.550 0.871 (0.449–1.688) 0.682
Serum ALT, U/L (≤ 40 vs. > 40) 0.001 0.534 (0.335–0.848) 0.008 0.534 (0.335–0.848) 0.008 0.552 (0.346–0.879) 0.012
γ-GT, U/L (> 75 vs. ≤ 75) 0.023 1.295 (0.883–1.898) 0.185 1.295 (0.883–1.898) 0.185 1.257 (0.856–1.846) 0.243
Tumor size (cm) (>  5 vs. ≤ 5) < 0.0001 1.984 (1.461–2.696) < 0.0001 1.984 (1.461–2.696) < 0.0001 2.006 (1.474–2.729) < 0.0001
Tumor number (multiple vs. single) 0.001 1.451 (1.006–2.092) 0.046 1.451 (1.006–2.092) 0.046 1.432 (0.993–2.064) 0.054
Vascular invasion (yes vs. no) < 0.0001 1.701 (1.254–2.307) 0.001 1.701 (1.254–2.307) 0.001 1.695 (1.250–2.300) 0.001
TNM stage (I vs. II-III) < 0.0001 0.799 (0.388–1.647) 0.543 0.799 (0.388–1.647) 0.543 0.831 (0.404–1.710) 0.615
CD8+PD1Int/ CD8+PD1+ (high vs. low) 0.005 0.686 (0.497–0.947) 0.022     
CD8+PD1Hi/ CD8+PD1+
(high vs. low)
0.005    1.458 (1.056–2.013) 0.022   
CD8+TIM3+ PD1Hi/ CD8+PD1+ (high vs. low) 0.002      1.476 (1.085–2.008) 0.013
  1. Abbreviations: ALT Alanine transaminase, γ-GT Gamma-Glutamyl-transpeptidase, TNM Tumor-nodes-metastases, HR Hazard ratio, CI Confidential interval. A:CD8+PD1Int/ CD8+PD1+; B:CD8+PD1Hi/ CD8+PD1+; C:CD8+TIM3+PD1Hi/ CD8+PD1+. Multivariate analysis was performed by the Cox multivariate proportional hazard regression model with stepwise manner