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Table 3 Immunohistochemistry analysis of whole tumor and IM of pretreatment tumor biopsies

From: A phase Ib study of utomilumab (PF-05082566) in combination with mogamulizumab in patients with advanced solid tumors

Cancer TypeBOR%PD-L1+%CD8+ ALLa%FoxP3+ ALLaCD8/FoxP3 ALLa%CB8+ IMb%FoxP3+ IMb%CD137+ IMbCD8/FoxP3 IMb
  1. Marker-positive cells are reported as a percent of evaluated cells
  2. aALL: The region encompassing the tumor and extending up to the leading edge, but not outside the tumor-normal interface
  3. bIM: The region extending from 500 μm outside the leading edge of the tumor to 500 μm inside
  4. BOR Best overall response, NE Not evaluable, NSCLC Non–small-cell lung cancer, PD Progressive disease, PD-L1 Programmed cell death-ligand 1, PR Partial response, SCCHN Squamous cell cancer of head and neck, SD Stable disease