Fig. 4

Tumors with a higher tumor-to-stroma ratio (T:S) have an increased proportion of infiltrating CD8⁺ T cells expressing high levels of PD-1. A: Proportions of CD4⁺ and CD8⁺ T cells isolated from tumors (n = 24). B: Infiltration scores of tumor-infiltrating CD8⁺ and FoxP3⁺ cells in tumors with low (T:S < 1.5; blue) or high (T:S > 1.5; orange) T:S. C,D: Proportion of CD4⁺ (C) and CD8⁺ (D) T cells (n = 24) expressing high levels of PD-1. Whisker and box plots summarize data from tumors with low (T:S < 1.5; blue) or high (T:S > 1.5; orange) T:S. T:S of tumor is represented below by color gradient (A,C,D). Statistical significance was determined by Mann Whitney U test