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Fig. 6 | Journal for ImmunoTherapy of Cancer

Fig. 6

From: High expression of B7-H3 on stromal cells defines tumor and stromal compartments in epithelial ovarian cancer and is associated with limited immune activation

Fig. 6

Tumors from the same patient show strong correlation across expression of some immune features. A: Linear correlations between normalized expression of CD86 (r = 0.989; p = 0.011), PD-L1 (r = 1.0; p = 0.00049), CD40 (r = 0.829; p = 0.17), and ICOSL (r = 0.732; p = 0.27) on APCs (CD11c+HLA-DRhigh) isolated from two tumors within the same patient. B: Linear correlations between proportion of CD4+ (r = 0.953; p = 0.012) or CD8+ (r = − 0.308; p = 0.61) T cells isolated from two tumors within the same patient expressing high levels of PD-1. C: Linear correlations between the percentage of non-immune cells that are tumor cells (r = 0.656; p = 0.23) and the proportion of tumor cells expressing B7-H4 (r = 0.665; p = 0.22)

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