Fig. 3

Timeline of the patient’s clinical, therapeutic, and radiological course. The 11 cycles of nivolumab administration and its related onset and resolution of CNS demyelinating lesions are highlighted in red. A time reference has been included, with Day 0 referring to the day of onset of nivolumab treatment. Abbreviations: LN: lymph node; C: cycle; SRS: stereotactic radiosurgery; Dx: diagnosis; TT: treatment; DEX: dexamethasone; PD: progressive disease; PR: partial response; MRI: magnetic resonance imaging; CT: computed tomography; CNS: central nervous system. *5 mg/kg; **1 mg i.d. for 7 days, and 5.25 mg tapered over 14 days