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Table 1 Mutational burden in NXS2 vs 9464D-GD2 cells. Genomic analysis of tumor cell lines reveals that the 9464D and 9464D-GD2 neuroblastoma cell lines have lower mutation burdens compared to the NXS2 neuroblastoma cell line. All 3 lines show TP53 mutations

From: Combined innate and adaptive immunotherapy overcomes resistance of immunologically cold syngeneic murine neuroblastoma to checkpoint inhibition

Tumor

TMB (Mutations/Megabase)

TP53 Mutations

Mouse

Human Homolog

NXS2

13.9

V167 L

V173 L

Parental 9464D

1.5

A132P

A138P

9464D-GD2

1.6

A132P

A138P