Fig. 2

Senescence of peripheral blood Vδ2^pos T cell in patients affected by liver metastasis of colorectal cancer and underwent chemotherapy. a Statistical analysis showing the correlations between the frequencies (%) of Vδ2^pos T_EMRA and CD57^pos/Vδ2^pos T and in CLM patients underwent CHT (n = 40). b Statistical dot plot (left) and representative histogram (right) graphs showing the expressions (%) of CD57 on matching T_CM, T_EM and T_EMRA Vδ2^pos T cell subsets in CLM patients underwent CHT (n = 15). c Statistical bar graphs showing the fold change increases of CD107a expression as well as of intracellular amounts of IFN-γ and TNF-α by CD57^neg and CD57^pos Vδ2 T cell effector subsets (i.e. T_EMRA and T_EM) from CLM patients underwent CHT and following in vitro stimulation with PMA and Ionomycin (n = 6). d Statistical dot plot analysis showing the expressions (%) of CD57 and the frequencies (%) of T_EMRA within Vδ2^pos T cell compartments in CLM patients underwent CHT and divided in two groups of respectively < (white circles; n = 18) and ≥ (black circles; n = 21) of 60 years old. The mean age of the entire cohort of CLM patients underwent CHT is of 61 ± 10.7 years old as shown in statistical graph on right upper side. e Statistical dot plot analysis showing the expressions (%) of CD57 on Vδ2^pos T_EMRA cells from CLM patients underwent CHT and under 60 years old (n = 16) compared to age-matched healthy donors (n = 16). f Statistical analysis showing the correlations between the surface levels (%) of CD57 and CD28 (n = 51) (left graph) or CD16 (n = 51) (right graph) on Vδ2^pos T cells in CLM patients underwent CHT