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Fig. 5 | Journal for ImmunoTherapy of Cancer

Fig. 5

From: Tumor microenvironment-derived S100A8/A9 is a novel prognostic biomarker for advanced melanoma patients and during immunotherapy with anti-PD-1 antibodies

Fig. 5

Elevated baseline S100A8/A9 serum levels are associated with impaired survival in patients treated with pembrolizumab. Kaplan-Meier survival curves for overall survival and progression-free survival stratified by normal (≤5.5 mg/l) or elevated (> 5.5 mg/l) S100A8/A9 serum levels in patients treated with the PD-1 antibody pembrolizumab in (a) pembrolizumab set 1 (27 patients), and in (b) pembrolizumab set 2 (44 patients), respectively. Hazard ratios were calculated using univariate Cox regression. Numbers in brackets indicate 95% confidence intervals. P-values were calculated using two-sided Log-Rank test. Abbreviations: HR = hazard ratio, P = P-value

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