| Training set | Independent validation set | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Patients | Â | Patients | Â | |||||||||
N | % | % Dead | HR | 95% CI | P | N | % | % Dead | HR | 95% CI | P | |
S100A8/A9 | ||||||||||||
 ≤ 5.5 mg/l | 81 | 71.1 | 35.8 | 1 |  |  | 170 | 70.8 | 22.4 | 1 |  |  |
 > 5.5 mg/l | 33 | 28.9 | 69.7 | 2.74 | 1.37–5.46 | .0043 | 70 | 29.2 | 45.7 | 1.79 | 1.06–3.02 | .030 |
S100B | ||||||||||||
 ≤ 0.1 μg/l | 80 | 70.2 | 35.0 | 1 |  |  | 190 | 79.2 | 18.4 | 1 |  |  |
 > 0.1 μg/l | 34 | 29.8 | 70.6 | 1.61 | 0.75–3.43 | .22 | 50 | 20.8 | 70.0 | 3.31 | 1.82–6.03 | <.0001 |
LDH | ||||||||||||
 ≤ ULN | 84 | 73.7 | 40.5 | 1 |  |  | 205 | 85.4 | 25.4 | 1 |  |  |
 > ULN | 30 | 26.3 | 60.0 | 1.68 | 0.68–4.12 | .26 | 35 | 14.6 | 51.4 | 1.35 | 0.72–2.54 | .35 |