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  1. Unlike some adult cancers, most pediatric cancers are considered immunologically cold and generally less responsive to immunotherapy. While immunotherapy has already been incorporated into standard of care tre...

    Authors: Julie Voeller, Amy K. Erbe, Jacob Slowinski, Kayla Rasmussen, Peter M. Carlson, Anna Hoefges, Sabrina VandenHeuvel, Ashley Stuckwisch, Xing Wang, Stephen D. Gillies, Ravi B. Patel, Alvin Farrel, Jo Lynne Rokita, John Maris, Jacquelyn A. Hank, Zachary S. Morris…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:344

    Content type: Research article

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  2. Predicting metastasis in melanoma patients is important for disease management and could help to identify those who might benefit from adjuvant treatment. The aim of this study was to investigate whether the t...

    Authors: Nikolaus B. Wagner, Benjamin Weide, Mirko Gries, Maike Reith, Kathrin Tarnanidis, Valerie Schuermans, Charlotte Kemper, Coretta Kehrel, Anne Funder, Ramtin Lichtenberger, Antje Sucker, Esther Herpel, Tim Holland-Letz, Dirk Schadendorf, Claus Garbe, Viktor Umansky…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:343

    Content type: Research article

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  3. Expressed on activated T and natural killer cells, 4-1BB/CD137 is a costimulatory receptor that signals a series of events resulting in cytokine secretion and enhanced effector function. Targeting 4-1BB/CD137 ...

    Authors: Ezra E. W. Cohen, Michael J. Pishvaian, Dale R. Shepard, Ding Wang, Jared Weiss, Melissa L. Johnson, Christine H. Chung, Ying Chen, Bo Huang, Craig B. Davis, Francesca Toffalorio, Aron Thall and Steven F. Powell

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:342

    Content type: Research article

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  4. Deciphering the correlation between immune-related adverse events (irAEs) categorized by organ system class and clinical benefit of immunotherapy is critical for clinical practice. The aim of this study is to ...

    Authors: Puyuan Xing, Fan Zhang, Guoqiang Wang, Yu Xu, Chengcheng Li, Shouzheng Wang, Yiying Guo, Shangli Cai, Yan Wang and Junling Li

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:341

    Content type: Review

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  5. Accumulating preclinical data indicate that targeting the SIRPα/CD47 axis alone or in combination with existing targeted therapies or immune checkpoint inhibitors enhances tumor rejection. Although several CD4...

    Authors: Erik Voets, Marc Paradé, David Lutje Hulsik, Sanne Spijkers, Wout Janssen, Joost Rens, Inge Reinieren-Beeren, Gilbert van den Tillaart, Sander van Duijnhoven, Lilian Driessen, Maurice Habraken, Peter van Zandvoort, Joost Kreijtz, Paul Vink, Andrea van Elsas and Hans van Eenennaam

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:340

    Content type: Research article

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  6. Regulatory T (Treg) cells have an immunosuppressive function in cancer, but the underlying mechanism of immunosuppression in the tumor microenvironment (TME) is unclear.

    Authors: Hye Ryun Kim, Hyo Jin Park, Jimin Son, Jin Gu Lee, Kyung Young Chung, Nam Hoon Cho, Hyo Sup Shim, Seyeon Park, Gamin Kim, Hong In Yoon, Hyun Gyung Kim, Yong Woo Jung, Byoung Chul Cho, Seong Yong Park, Sun Young Rha and Sang-Jun Ha

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:339

    Content type: Research article

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  7. Cutaneous squamous cell carcinoma (cSCC) is not uncommon in association with indolent malignancies that were treated with prior radiotherapy and after allogenic bone marrow transplantation. On the other hand, ...

    Authors: Karam Khaddour, Amy Musiek, Lynn A. Cornelius, Farrokh Dehdashti, Peter Westervelt, Ryan Fields and George Ansstas

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:338

    Content type: Case report

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  8. Paraneoplastic syndromes (PNS) are autoimmune disorders specifically associated with cancer. There are few data on anti-PD-1 or anti-PD-L1 immunotherapy in patients with a PNS. Our objective was to describe th...

    Authors: Guillaume Manson, Alexandre Thibault Jacques Maria, Florence Poizeau, François-Xavier Danlos, Marie Kostine, Solenn Brosseau, Sandrine Aspeslagh, Pauline Du Rusquec, Maxime Roger, Maud Pallix-Guyot, Marc Ruivard, Léa Dousset, Laurianne Grignou, Dimitri Psimaras, Johan Pluvy, Gilles Quéré…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:337

    Content type: Research article

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  9. Immune checkpoint inhibitors (ICPis) have revolutionised the treatment of melanoma by significantly increasing survival rates and disease control. However, ICPis can have specific immune-related adverse events...

    Authors: Vincent Pillonel, Vincent Dunet, Andreas F. Hottinger, Gregoire Berthod, Luis Schiappacasse, Solange Peters, Olivier Michielin and Veronica Aedo-Lopez

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:336

    Content type: Case report

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  10. Following publication of the original article [1], the authors reported that authors’ given and family names haven been incorrectly tagged.

    Authors: Anastasia Saade, Audrey Mansuet-Lupo, Jennifer Arrondeau, Constance Thibault, Mariana Mirabel, François Goldwasser, Stéphane Oudard and Laurence Weiss

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:335

    Content type: Correction

    Published on:

    The original article was published in Journal for ImmunoTherapy of Cancer 2019 7:266

  11. Immune checkpoint inhibitors have achieved unprecedented success in cancer immunotherapy. With the exception of a few candidate biomarkers, the prognostic role of soluble immune checkpoint-related proteins in ...

    Authors: Qinchuan Wang, Jinhua Zhang, Huakang Tu, Dong Liang, David. W. Chang, Yuanqing Ye and Xifeng Wu

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:334

    Content type: Research article

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  12. Hepatocellular carcinoma (HCC) is the second deadliest cancer worldwide, due to its high incidence and poor prognosis. Frequent initial presentation at advanced stages along with impaired liver function limit ...

    Authors: Marc Hilmi, Cindy Neuzillet, Julien Calderaro, Fouad Lafdil, Jean-Michel Pawlotsky and Benoit Rousseau

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:333

    Content type: Review

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  13. Immunotherapy is now widely established as a potent and effective treatment option across several types of cancer. However, there is increasing recognition that not all patients respond to immunotherapy, focus...

    Authors: Paolo A. Ascierto, Carlo Bifulco, Luigi Buonaguro, Leisha A. Emens, Robert L. Ferris, Bernard A. Fox, Greg M. Delgoffe, Jérôme Galon, Cesare Gridelli, Marco Merlano, Paul Nathan, Kunle Odunsi, Hideho Okada, Chrystal M. Paulos, Sandro Pignata, Kurt A. Schalper…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:332

    Content type: Review

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  14. CD8+ T cells differentiate into exhausted status within tumors, including hepatocellular carcinoma (HCC), which constitutes a solid barrier to effective anti-tumor immunity. A detailed characterization of exhaust...

    Authors: Jiaqiang Ma, Bohao Zheng, Shyamal Goswami, Lu Meng, Dandan Zhang, Chunmei Cao, Teng Li, Fangming Zhu, Lijie Ma, Zhao Zhang, Shuhao Zhang, Meng Duan, Qin Chen, Qiang Gao and Xiaoming Zhang

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:331

    Content type: Research article

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  15. Pre-clinical and clinical studies have shown that the infusion of CAR T cells with a naive-like (TN) and central memory (TCM) phenotype is associated with prolonged in vivo T cell persistence and superior anti-tu...

    Authors: Alejandro Torres Chavez, Mary Kathryn McKenna, Emanuele Canestrari, Christina T. Dann, Carlos A. Ramos, Premal Lulla, Ann M. Leen, Juan F. Vera and Norihiro Watanabe

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:330

    Content type: Research article

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  16. Currently, there are no imaging predictors of immunotherapy outcome in hepatocellular carcinoma (HCC). The study aim was to determine if stiffness changes measured by magnetic resonance elastography (MRE) can ...

    Authors: Aliya Qayyum, Ken-Pin Hwang, Jason Stafford, Anuj Verma, Dipen M. Maru, Subramanya Sandesh, Jia Sun, Roberto Carmagnani Pestana, Rony Avritscher, Manal M. Hassan, Hesham Amin, Asif Rashid, Ignacio I. Wistuba, Richard L. Ehman, Jingfei Ma and Ahmed O. Kaseb

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:329

    Content type: Short report

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  17. The ability to modulate immune-inhibitory pathways using checkpoint blockade antibodies such as αPD-1, αPD-L1, and αCTLA-4 represents a significant breakthrough in cancer therapy in recent years. This has driv...

    Authors: Molly A. Taylor, Adina M. Hughes, Josephine Walton, Anna M. L. Coenen-Stass, Lukasz Magiera, Lorraine Mooney, Sigourney Bell, Anna D. Staniszewska, Linda C. Sandin, Simon T. Barry, Amanda Watkins, Larissa S. Carnevalli and Elizabeth L. Hardaker

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:328

    Content type: Research article

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  18. Programmed death-1 (PD-1) immune checkpoint blockade has achieved clinical successes in cancer therapy. However, the response rate of anti-PD-1 agents remains low. Additionally, a subpopulation of patients dev...

    Authors: Douglas D. Fang, Qiuqiong Tang, Yanhui Kong, Qixin Wang, Jiaxing Gu, Xu Fang, Peng Zou, Tao Rong, Jingwen Wang, Dajun Yang and Yifan Zhai

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:327

    Content type: Research article

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  19. It is unclear whether plant-derived extracellular vesicles (EVs) can mediate interspecies communication with mammalian cells. Tumor-associated macrophages (TAMs) display a continuum of different polarization s...

    Authors: Meng Cao, Huaijiang Yan, Xuan Han, Ling Weng, Qin Wei, Xiaoyan Sun, Wuguang Lu, Qingyun Wei, Juan Ye, Xueting Cai, Chunping Hu, Xiaoyang Yin and Peng Cao

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:326

    Content type: Research article

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  20. The immunologic landscape of the host and tumor play key roles in determining how patients will benefit from immunotherapy, and a better understanding of these factors could help inform how well a tumor respon...

    Authors: Andrew B. Nixon, Kurt A. Schalper, Ira Jacobs, Shobha Potluri, I-Ming Wang and Catherine Fleener

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:325

    Content type: Review

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  21. The IL-17 family cytokines are potent drivers of colorectal cancer (CRC) development. We and others have shown that IL-17 mainly signals to tumor cells to promote CRC, but the underlying mechanism remains uncl...

    Authors: Ju Chen, Xiaoyang Ye, Elise Pitmon, Mengqian Lu, Jun Wan, Evan R. Jellison, Adam J. Adler, Anthony T. Vella and Kepeng Wang

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:324

    Content type: Research article

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  22. Tumors that lack pre-existing immune infiltration respond poorly to T cell checkpoint blockade immunotherapy. These cancers often surround themselves with high densities of suppressive myeloid stroma while exc...

    Authors: Matthew J. Reilley, Brittany Morrow, Casey R. Ager, Arthur Liu, David S. Hong and Michael A. Curran

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:323

    Content type: Short report

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  23. Hepatitis B virus (HBV) reactivation is a serious complication in patients with cancers and HBV infection undergoing immunosuppressant treatment or chemotherapy. However, the safety of anti-programmed cell dea...

    Authors: Xuanye Zhang, Yixin Zhou, Chen Chen, Wenfeng Fang, Xiuyu Cai, Xiaoshi Zhang, Ming Zhao, Bei Zhang, Wenqi Jiang, Zuan Lin, Yuxiang Ma, Yunpeng Yang, Yan Huang, Hongyun Zhao, Ruihua Xu, Shaodong Hong…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:322

    Content type: Research article

    Published on:

  24. Dendritic cell (DC) vaccine efficacy is directly related to the efficiency of DC migration to the lymph node after delivery to the patient. We discovered that a naturally occurring metabolite, sarcosine, incre...

    Authors: Farhad Dastmalchi, Aida Karachi, Changlin Yang, Hassan Azari, Elias Joseph Sayour, Anjelika Dechkovskaia, Alexander Loren Vlasak, Megan Ellen Saia, Rolando Eladio Lovaton, Duane Anthony Mitchell and Maryam Rahman

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:321

    Content type: Research article

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  25. Tumour-associated macrophages (TAMs) are often implicated in cancer progression but can also exert anti-tumour activities. Selective eradication of cancer-promoting (M2-like) TAM subsets is a highly sought-aft...

    Authors: Eleanor M. Scott, Egon J. Jacobus, Brian Lyons, Sally Frost, Joshua D. Freedman, Arthur Dyer, Hena Khalique, William K. Taverner, Alison Carr, Brian R. Champion, Kerry D. Fisher, Len W. Seymour and Margaret R. Duffy

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:320

    Content type: Research article

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  26. Myasthenia gravis (MG) is a rare but life-threatening adverse event of immune checkpoint inhibitors (ICI). Given the limited evidence, data from a large cohort of patients is needed to aid in recognition and m...

    Authors: Houssein Safa, Daniel H Johnson, Van Anh Trinh, Theresa E Rodgers, Heather Lin, Maria E Suarez-Almazor, Faisal Fa’ak, Chantal Saberian, Cassian Yee, Michael A Davies, Sudhakar Tummala, Karin Woodman, Noha Abdel-Wahab and Adi Diab

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:319

    Content type: Research article

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  27. Programmed cell death protein 1 (PD-1) blockade is only effective in a minority of patients, prompting the search for combinatorial therapies that increase responses. Identifying effective combinations require...

    Authors: Sandra Demaria, Emanuela Romano, Muriel Brackstone and Silvia C. Formenti

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:318

    Content type: Commentary

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  28. Neurologic complications as myelitis are very rare but extremely deleterious adverse effects of both immunotherapy and radiotherapy. Many recent studies have focused on the possible synergy of these two treatm...

    Authors: Marcela Carausu, Arnaud Beddok, Adriana Langer, Nicolas Girard, François-Clément Bidard, Marie-Ange Massiani, Damien Ricard and Luc Cabel

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:317

    Content type: Case report

    Published on:

  29. Bone metastases (BoM) are a negative prognostic factor in non-small-cell lung cancer (NSCLC). Beyond its supportive role, bone is a hematopoietic organ actively regulating immune system. We hypothesized that B...

    Authors: Lorenza Landi, Federica D’Incà, Alain Gelibter, Rita Chiari, Francesco Grossi, Angelo Delmonte, Antonio Passaro, Diego Signorelli, Francesco Gelsomino, Domenico Galetta, Diana Giannarelli, Hector Soto Parra, Gabriele Minuti, Marcello Tiseo, Maria Rita Migliorino, Francesco Cognetti…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:316

    Content type: Research article

    Published on:

  30. Hepatitis B virus (HBV) reactivation is commonly seen in HBsAg-positive hematologic patients undergoing immunosuppressive chemotherapy. Little is known about the risk of HBV reactivation after chimeric antigen...

    Authors: Jia Wei, Xiaojian Zhu, Xia Mao, Liang Huang, Fankai Meng and Jianfeng Zhou

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:315

    Content type: Case report

    Published on:

  31. The iMATRIX-atezolizumab study was a phase I/II, multicenter, open-label study designed to assess the safety and pharmacokinetics of atezolizumab in pediatric and young adult patients. We describe the pharmaco...

    Authors: Colby S. Shemesh, Pascal Chanu, Kris Jamsen, Russ Wada, Gianluca Rossato, Francis Donaldson, Amit Garg, Helen Winter, Jane Ruppel, Xin Wang, Rene Bruno, Jin Jin and Sandhya Girish

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:314

    Content type: Research article

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  32. The standard treatment for epithelial ovarian carcinoma (EOC) is surgery followed by platinum/paclitaxel-based chemotherapy, but the overall survival rate is poor. The purpose of this study was to investigate ...

    Authors: Yu-Li Chen, Han-Wei Lin, Chung-Liang Chien, Yen-Ling Lai, Wei-Zen Sun, Chi-An Chen and Wen-Fang Cheng

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:313

    Content type: Research article

    Published on:

  33. Adjuvanticity, which is the ability of neoplastic cells to deliver danger signals, is critical for the host immune system to mount spontaneous and therapy-driven anticancer immune responses. One of such signals, ...

    Authors: Lenka Kasikova, Michal Hensler, Iva Truxova, Petr Skapa, Jan Laco, Lucie Belicova, Ivan Praznovec, Sarka Vosahlikova, Michael J. Halaska, Tomas Brtnicky, Lukas Rob, Jiri Presl, Jan Kostun, Isabelle Cremer, Ales Ryska, Guido Kroemer…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:312

    Content type: Research article

    Published on:

  34. TNF receptor family agonists and checkpoint blockade combination therapies lead to minimal tumor clearance of poorly immunogenic tumors. Therefore, a need to enhance the efficacy of this combination therapy ar...

    Authors: Jaina M. Patel, Zhihua Cui, Zhi-Fa Wen, Catherine T. Dinh and Hong-Ming Hu

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:311

    Content type: Research article

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  35. Patient derived organoids (PDOs) can be established from colorectal cancers (CRCs) as in vitro models to interrogate cancer biology and its clinical relevance. We applied mass spectrometry (MS) immunopeptidomi...

    Authors: Alice Newey, Beatrice Griffiths, Justine Michaux, Hui Song Pak, Brian J. Stevenson, Andrew Woolston, Maria Semiannikova, Georgia Spain, Louise J. Barber, Nik Matthews, Sheela Rao, David Watkins, Ian Chau, George Coukos, Julien Racle, David Gfeller…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:309

    Content type: Research article

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  36. Eosinophilia has been reported as a rare, new biological effect of immune checkpoint inhibition that may be associated with improved treatment response and the development of immune-related adverse events.

    Authors: J. Yang, S. M. Lagana, Y. M. Saenger and R. D. Carvajal

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:310

    Content type: Case report

    Published on:

  37. Clinical response to MAPK inhibitors in metastatic melanoma patients is heterogeneous for reasons still needing to be elucidated. As the patient immune activity contributes to treatment clinical benefit, the p...

    Authors: Daniela Massi, Eliana Rulli, Mara Cossa, Barbara Valeri, Monica Rodolfo, Barbara Merelli, Francesco De Logu, Romina Nassini, Michele Del Vecchio, Lorenza Di Guardo, Roberta De Penni, Michele Guida, Vanna Chiarion Sileni, Anna Maria Di Giacomo, Marco Tucci, Marcella Occelli…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:308

    Content type: Research article

    Published on:

  38. We previously showed that the bacterial lipopeptide Pam3Cys-Ser-Ser, meanwhile established as a toll-like receptor (TLR) 1/2 ligand, acts as a strong adjuvant for the induction of virus specific CD8+ T cells in m...

    Authors: Hans-Georg Rammensee, Karl-Heinz Wiesmüller, P. Anoop Chandran, Henning Zelba, Elisa Rusch, Cécile Gouttefangeas, Daniel J. Kowalewski, Moreno Di Marco, Sebastian P. Haen, Juliane S. Walz, Yamel Cardona Gloria, Johanna Bödder, Jill-Marie Schertel, Antje Tunger, Luise Müller, Maximilian Kießler…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:307

    Content type: Research article

    Published on:

  39. The PD-1/PD-L1 checkpoint is a central mediator of immunosuppression in the tumor immune microenvironment (TME) and is primarily associated with IFN-g signaling. To characterize other factors regulating PD-L1 ...

    Authors: Shuming Chen, George A. Crabill, Theresa S. Pritchard, Tracee L. McMiller, Ping Wei, Drew M. Pardoll, Fan Pan and Suzanne L. Topalian

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:305

    Content type: Research article

    Published on:

  40. Despite remarkable success in the treatment of hematological malignancies, CAR T-cell therapies for solid tumors have floundered, in large part due to local immune suppression and the effects of prolonged stim...

    Authors: Bryan D. Choi, Xiaoling Yu, Ana P. Castano, Henia Darr, Daniel B. Henderson, Amanda A. Bouffard, Rebecca C. Larson, Irene Scarfò, Stefanie R. Bailey, Genevieve M. Gerhard, Matthew J. Frigault, Mark B. Leick, Andrea Schmidts, Jason G. Sagert, William T. Curry, Bob S. Carter…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:304

    Content type: Short report

    Published on:

  41. Immune checkpoint blockers (ICB) have revolutionized cancer therapy. However, complete response is observed in a minority of patients and most patients develop immune-related adverse events (irAEs). These incl...

    Authors: Anne Montfort, Carine Dufau, Céline Colacios, Nathalie Andrieu-Abadie, Thierry Levade, Thomas Filleron, Jean-Pierre Delord, Maha Ayyoub, Nicolas Meyer and Bruno Ségui

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:303

    Content type: Commentary

    Published on:

  42. Clinical benefit of cellular immunotherapy has been shown in patients with castration-resistant prostate cancer (CRPC). We investigated the immunological response and clinical outcome of vaccination with blood-de...

    Authors: Harm Westdorp, Jeroen H. A. Creemers, Inge M. van Oort, Gerty Schreibelt, Mark A. J. Gorris, Niven Mehra, Michiel Simons, Anna L. de Goede, Michelle M. van Rossum, Alexandra J. Croockewit, Carl G. Figdor, J. Alfred Witjes, Erik H. J. G. Aarntzen, Roel D. M. Mus, Mareke Brüning, Katja Petry…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:302

    Content type: Research article

    Published on:

  43. Despite chemo-induction therapy and autologous stem cell transplantation (ASCT), the vast majority of patients with Multiple Myeloma (MM) relapse within 7 years and the disease remains incurable. Adoptive Allo...

    Authors: S. Yado, G. Luboshits, O. Hazan, R. Or and M. A. Firer

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:301

    Content type: Research article

    Published on:

  44. Accumulating studies suggest that targeting epigenetic modifications could improve the efficacy of tumor immunotherapy; however, the mechanisms underlying this phenomenon remain largely unknown. Here, we inves...

    Authors: Gang Xiao, Li-Lian Jin, Chao-Qun Liu, Yong-Chun Wang, Ya-Ming Meng, Zhong-Guo Zhou, Jing Chen, Xing-Juan Yu, Yao-Jun Zhang, Jing Xu and Limin Zheng

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:300

    Content type: Research article

    Published on:

  45. Uveal melanoma (UM) is highly refractory to treatment with dismal prognosis in advanced stages. The value of the combined checkpoint blockade with CTLA-4 and PD-1 inhibition in metastatic UM is currently unclear.

    Authors: Markus V. Heppt, Teresa Amaral, Katharina C. Kähler, Lucie Heinzerling, Jessica C. Hassel, Markus Meissner, Nicole Kreuzberg, Carmen Loquai, Lydia Reinhardt, Jochen Utikal, Evelyn Dabrowski, Anja Gesierich, Claudia Pföhler, Patrick Terheyden, Kai-Martin Thoms, Lisa Zimmer…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:299

    Content type: Research article

    Published on:

  46. Immunotherapy, especially immune checkpoint inhibition, has provided powerful tools against cancer. We aimed to detect the expression of common immune checkpoints and evaluate their prognostic values in nasoph...

    Authors: Ya-Qin Wang, Yu Zhang, Wei Jiang, Yu-Pei Chen, Shuo-Yu Xu, Na Liu, Yin Zhao, Li Li, Yuan Lei, Xiao-Hong Hong, Ye-Lin Liang, Jun-Yan Li, Lu-Lu Zhang, Jing-Ping Yun, Ying Sun, Ying-Qin Li…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:298

    Content type: Research article

    Published on:

  47. Analysis of deficiency in DNA mismatch repair (dMMR) is currently considered a standard molecular test in all patients with colorectal cancer (CRC) for its implications in screening, prognosis and prediction o...

    Authors: Fotios Loupakis, Giulia Maddalena, Ilaria Depetris, Sabina Murgioni, Francesca Bergamo, Angelo Paolo Dei Tos, Massimo Rugge, Giada Munari, Andrew Nguyen, Christopher Szeto, Vittorina Zagonel, Sara Lonardi and Matteo Fassan

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:297

    Content type: Case report

    Published on:

  48. Adoptive transfer of autologous T-lymphocytes transduced with a high affinity NY-ESO-1-reactive T-cell receptor (NY-ESO-1c259 T-cells) has emerged as a promising therapeutic strategy for patients with refractory ...

    Authors: Jocelyn Joseph, Michael J. Nathenson, Van Anh Trinh, Karan Malik, Erica Nowell, Kristen Carter, Shiao-Pei Weathers, George D. Demetri, Dejka Araujo and Anthony P. Conley

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:296

    Content type: Case report

    Published on:

  49. The most common metastatic lesions of prostate cancer are in bone and can be classified into three distinct pathology subtypes: lytic, blastic, and an indeterminate mixture of both. We investigated a cohort of...

    Authors: Claire L. Ihle, Meredith D. Provera, Desiree M. Straign, E. Erin Smith, Susan M. Edgerton, Adrie Van Bokhoven, M. Scott Lucia and Philip Owens

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:293

    Content type: Short report

    Published on:

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