Case Reports

Section edited by Alfred Zippelius, MD

Reports on unusual or unexpected clinical cases that expand the field of general medical knowledge. Includes information on an unexpected association between diseases or symptoms, an unexpected event in the course of observing or treating a patient, findings that shed new light on the possible pathogenesis of the disease or an adverse effect, unique or rare features of the disease, and/or a unique therapeutic approach.

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  1. Case report

    Genetic risk analysis of a patient with fulminant autoimmune type 1 diabetes mellitus secondary to combination ipilimumab and nivolumab immunotherapy

    Checkpoint inhibitor immunotherapy is becoming an effective treatment modality for an increasing number of malignancies. As a result, autoinflammatory side-effects are also being observed more commonly in the ...

    Jared R. Lowe, Daniel J. Perry, April K. S. Salama, Clayton E. Mathews, Larry G. Moss and Brent A. Hanks

    Journal for ImmunoTherapy of Cancer 2016 4:89

    Published on: 20 December 2016

  2. Case report

    Sarcoidosis in the setting of combination ipilimumab and nivolumab immunotherapy: a case report & review of the literature

    We report a case of sarcoidosis in a patient with metastatic melanoma managed with combination ipilimumab/nivolumab. Sarcoid development has been linked with single agent immunotherapy but, to our knowledge, i...

    Joshua E. Reuss, Paul R. Kunk, Anne M. Stowman, Alejandro A. Gru, Craig L. Slingluff Jr. and Elizabeth M. Gaughan

    Journal for ImmunoTherapy of Cancer 2016 4:94

    Published on: 20 December 2016

  3. Case report

    Responses of metastatic basal cell and cutaneous squamous cell carcinomas to anti-PD1 monoclonal antibody REGN2810

    Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (CSCC) share exposure to UV light as the dominant risk factor, and these tumors therefore harbor high mutation burdens. In other malignancies, h...

    Gerald S. Falchook, Rom Leidner, Elizabeth Stankevich, Brian Piening, Carlo Bifulco, Israel Lowy and Matthew G. Fury

    Journal for ImmunoTherapy of Cancer 2016 4:70

    Published on: 15 November 2016

  4. Case report

    Recurrent pleural effusions and cardiac tamponade as possible manifestations of pseudoprogression associated with nivolumab therapy– a report of two cases

    Checkpoint inhibitors are a class of agents that employ host’s adaptive immune defenses in fighting cancer. With many new indications and several ongoing clinical trials in a variety of malignancies, the usage...

    Bhaskar C. Kolla and Manish R. Patel

    Journal for ImmunoTherapy of Cancer 2016 4:80

    Published on: 15 November 2016

  5. Case report

    PD1/PD-L1 inhibition as a potential radiosensitizer in head and neck squamous cell carcinoma: a case report

    Immunotherapy targeting the checkpoint PD1 (programmed cell death protein 1) or PDL1 (programmed death ligand 1) has led to advances in the treatment of melanoma and non-small cell lung cancer (NSCLC). The use...

    Misako Nagasaka, Mark Zaki, Harold Kim, S. Naweed Raza, George Yoo, Ho-sheng Lin and Ammar Sukari

    Journal for ImmunoTherapy of Cancer 2016 4:83

    Published on: 15 November 2016

  6. Case report

    Metastatic Merkel cell carcinoma response to nivolumab

    Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine malignancy with limited treatment options. Several lines of evidence support the programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) ...

    Frances M. Walocko, Benjamin Y. Scheier, Paul W. Harms, Leslie A. Fecher and Christopher D. Lao

    Journal for ImmunoTherapy of Cancer 2016 4:79

    Published on: 15 November 2016

    The Erratum to this article has been published in Journal for ImmunoTherapy of Cancer 2017 5:27

  7. Case report

    Acute visual loss after ipilimumab treatment for metastatic melanoma

    Ipilimumab, a humanized CLTA-4 antibody is a standard therapy in the treatment of advanced melanoma. While ipilimumab provides an overall survival benefit to patients, it can be associated with immune related ...

    Melissa A. Wilson, Kelly Guld, Steven Galetta, Ryan D. Walsh, Julia Kharlip, Madhura Tamhankar, Suzanne McGettigan, Lynn M. Schuchter and Leslie A. Fecher

    Journal for ImmunoTherapy of Cancer 2016 4:66

    Published on: 18 October 2016

  8. Case report

    Urothelial carcinoma of donor origin in a kidney transplant patient

    Malignancy after transplantation is an uncommon multifactorial occurrence. Immunosuppression to prevent graft rejection is described as a major risk factor in malignancy development in the post-transplant stat...

    Rosa M. Michel Ortega, Daynna J. Wolff, Cynthia A. Schandl and Harry A. Drabkin

    Journal for ImmunoTherapy of Cancer 2016 4:63

    Published on: 18 October 2016

  9. Case report

    Antitumor activity of nivolumab on hemodialysis after renal allograft rejection

    Nivolumab (Opdivo™) is a novel IgG4 subclass programmed death-1 (PD-1) inhibiting antibody that has demonstrated breakthrough-designation anti-tumor activity. To date, clinical trials of nivolumab and other ch...

    Michael Ong, Andrea Marie Ibrahim, Samuel Bourassa-Blanchette, Christina Canil, Todd Fairhead and Greg Knoll

    Journal for ImmunoTherapy of Cancer 2016 4:64

    Published on: 18 October 2016

  10. Case report

    A case report of Grover’s disease from immunotherapy-a skin toxicity induced by inhibition of CTLA-4 but not PD-1

    Immune related adverse events (irAEs) are common side effects of checkpoint inhibitory (CPI) therapies targeting CTLA-4 and PD-1/PD-L1. Grover’s disease is an uncommon dermatologic condition with unclear patho...

    Marc Uemura, Faisal Faˈak, Cara Haymaker, Natalie McQuail, Elizabeth Sirmans, Courtney W. Hudgens, Lydia Barbara, Chantale Bernatchez, Jonathan L. Curry, Patrick Hwu, Michael T. Tetzlaff and Adi Diab

    Journal for ImmunoTherapy of Cancer 2016 4:55

    Published on: 20 September 2016

    The Erratum to this article has been published in Journal for ImmunoTherapy of Cancer 2017 5:7

  11. Case report

    Increased FDG avidity in lymphoid tissue associated with response to combined immune checkpoint blockade

    Antibodies against programmed death 1 (PD-1) receptor and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) have transformed the systemic treatment of melanoma and many other cancers. Understanding the spec...

    Katy K. Tsai, Miguel H. Pampaloni, Charity Hope, Alain P. Algazi, Britt-Marie Ljung, Laura Pincus and Adil I. Daud

    Journal for ImmunoTherapy of Cancer 2016 4:58

    Published on: 20 September 2016

  12. Short report

    Cardiotoxicity associated with CTLA4 and PD1 blocking immunotherapy

    Immune-checkpoint blocking antibodies have demonstrated objective antitumor responses in multiple tumor types including melanoma, non-small cell lung cancer (NSCLC), and renal cell cancer (RCC). In melanoma, a...

    Lucie Heinzerling, Patrick A. Ott, F. Stephen Hodi, Aliya N. Husain, Azadeh Tajmir-Riahi, Hussein Tawbi, Matthias Pauschinger, Thomas F. Gajewski, Evan J. Lipson and Jason J. Luke

    Journal for ImmunoTherapy of Cancer 2016 4:50

    Published on: 16 August 2016

  13. Case report

    Grover’s-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy

    Dermatologic toxicity is an important adverse effect of immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death 1 receptor (PD-1) or PD ligand 1 (P...

    Viktor H. Koelzer, Tobias Buser, Niels Willi, Sacha I. Rothschild, Andreas Wicki, Peter Schiller, Gieri Cathomas, Alfred Zippelius and Kirsten D. Mertz

    Journal for ImmunoTherapy of Cancer 2016 4:47

    Published on: 16 August 2016

  14. Case report

    Acute rhabdomyolysis with severe polymyositis following ipilimumab-nivolumab treatment in a cancer patient with elevated anti-striated muscle antibody

    Immune checkpoint inhibitors have revolutionized cancer therapy since these drugs target inhibitory pathways on T cells, which result in durable anti-tumor immune responses and significant overall survival for...

    Mehmet Asim Bilen, Sumit K. Subudhi, Jianjun Gao, Nizar M. Tannir, Shi-Ming Tu and Padmanee Sharma

    Journal for ImmunoTherapy of Cancer 2016 4:36

    Published on: 21 June 2016

  15. Case report

    Disease stabilization with pembrolizumab for metastatic acral melanoma in the setting of autoimmune bullous pemphigoid

    To date, patients with pre-existing autoimmune conditions have been excluded from immunotherapy trials out of concern for severe autoimmune exacerbations.

    Kristen M. Beck, Joanna Dong, Larisa J. Geskin, Vincent P. Beltrani, Richard G. Phelps, Richard D. Carvajal, Gary Schwartz, Yvonne M. Saenger and Robyn D. Gartrell

    Journal for ImmunoTherapy of Cancer 2016 4:20

    Published on: 19 April 2016

  16. Case report

    Tumor control with PD-1 inhibition in a patient with concurrent metastatic melanoma and renal cell carcinoma

    Blockade of the immunological checkpoint programmed death 1 (PD-1) using monoclonal antibodies has shown robust anti-tumor activity across a broad range of solid and hematological malignancies including melano...

    Melina E. Marmarelis, Meredith R. Davis, Nilay S. Sethi, Katherine M. Krajewksi, Rana R. McKay, Toni K. Choueiri and Patrick A. Ott

    Journal for ImmunoTherapy of Cancer 2016 4:26

    Published on: 19 April 2016

  17. Case report

    Systemic inflammation in a melanoma patient treated with immune checkpoint inhibitors—an autopsy study

    Immune checkpoint inhibitors targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) have been recently approved for treatment of patients with metastatic mela...

    Viktor H. Koelzer, Sacha I. Rothschild, Deborah Zihler, Andreas Wicki, Berenika Willi, Niels Willi, Michèle Voegeli, Gieri Cathomas, Alfred Zippelius and Kirsten D. Mertz

    Journal for ImmunoTherapy of Cancer 2016 4:13

    Published on: 15 March 2016

  18. Case report

    Autoimmune inner ear disease in a melanoma patient treated with pembrolizumab

    Immune related adverse events affecting various organ systems are a recognized potential consequence of immune checkpoint inhibition. However, autoimmune inner ear disease is one complication not previously as...

    Matthew Zibelman, Natasha Pollak and Anthony J Olszanski

    Journal for ImmunoTherapy of Cancer 2016 4:8

    Published on: 16 February 2016

  19. Short report

    Ipilmumab and cranial radiation in metastatic melanoma patients: a case series and review

    Ipilimumab improves survival in metastatic melanoma patients. This population frequently develops brain metastases, which have been associated with poor survival and are often treated with radiation. Therefore...

    Jonathan D. Schoenfeld, Anand Mahadevan, Scott R. Floyd, Michael A. Dyer, Paul J. Catalano, Brian M. Alexander, David F. McDermott and Irving D. Kaplan

    Journal for ImmunoTherapy of Cancer 2015 3:50

    Published on: 15 December 2015

  20. Case report

    Mismatch repair deficiency associated with complete remission to combination programmed cell death ligand immune therapy in a patient with sporadic urothelial carcinoma: immunotheranostic considerations

    Mismatch repair deficiency (MMRD) is a common pathway of malignant transformation accounting for approximately 15–20 % of human carcinogensis. It has been postulated that MMRD increases tumor antigenicity and ...

    Michael P. Castro and Neal Goldstein

    Journal for ImmunoTherapy of Cancer 2015 3:58

    Published on: 15 December 2015

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