Section edited by Christian Capitini, MD

Reaction to and/or perspectives on significant events in the field in the basic science area. May address a critical challenge, elaborate or extend a conversation of a focal article, provide an application of a theoretical perspective, or shed light on a particular issue in the field.

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  1. Commentary

    A role for pre-mNK cells in tumor progression

    The innate and adaptive immune systems have evolved together to fight infection and cancerous tissues. The innate immune system emerges first with the adaptive immune system following, both ostensibly being br...

    Carolyn Rosinsky and Paul Andrew Antony

    Journal for ImmunoTherapy of Cancer 2016 4:16

    Published on: 15 March 2016

  2. Commentary

    The dark side of ID8-Luc2: pitfalls for luciferase tagged murine models for ovarian cancer

    Reliable mouse models are key in the discovery and development of novel anticancer treatments. Non-invasive monitoring techniques such as bioluminescence imaging (BLI) are useful tools to determine tumor engra...

    Thaïs Baert, Tina Verschuere, Anaïs Van Hoylandt, Rik Gijsbers, Ignace Vergote and An Coosemans

    Journal for ImmunoTherapy of Cancer 2015 3:57

    Published on: 15 December 2015

  3. Commentary

    A new paradigm for tumor immune escape: β-catenin-driven immune exclusion

    Increasing evidence is emerging that immunotherapeutic interventions, including checkpoint blockade, are predominantly effective in patients with a pre-existing T cell-inflamed tumor microenvironment. Understa...

    Stefani Spranger and Thomas F. Gajewski

    Journal for ImmunoTherapy of Cancer 2015 3:43

    Published on: 15 September 2015

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