Immunotherapy Biomarkers

Section edited by Lisa H. Butterfield, PhD

Predictive/prognostic biomarker studies, gene expression studies in cancer immunotherapy, serological immune biomarkers, multiparameter flow cytometry-defined immune biomarkers, high content immunohistological studies, clinical trial analyses and identification of novel immune biomarkers.

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  1. Research article

    Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma

    Adoptive T cell therapy (ACT) has shown great promise in melanoma, with over 50 % response rate in patients where autologous tumor-reactive tumor-infiltrating lymphocytes (TIL) can be cultured and expanded. A ...

    Zipei Feng, Sachin Puri, Tarsem Moudgil, William Wood, Clifford C. Hoyt, Chichung Wang, Walter J. Urba, Brendan D. Curti, Carlo B. Bifulco and Bernard A. Fox

    Journal for ImmunoTherapy of Cancer 2015 3:47

    Published on: 20 October 2015

  2. Research article

    Prognostic impact of circulating Her-2-reactive T-cells producing pro- and/or anti-inflammatory cytokines in elderly breast cancer patients

    Treating elderly breast cancer patients remains a challenge but the increasing availability of immunotherapeutic approaches instills optimism that these tumours may also be susceptible to immune control. Becau...

    Jithendra Kini Bailur, Evelyna Derhovanessian, Brigitte Gueckel and Graham Pawelec

    Journal for ImmunoTherapy of Cancer 2015 3:45

    Published on: 20 October 2015

  3. Short report

    Immune monitoring technology primer: clinical validation for predictive markers

    Recent biotechnological developments have resulted in increasing interest in immunology biomarkers. These biomarkers have potential clinical utility in the near future as predictors of treatment response. Henc...

    Kevin K. Dobbin

    Journal for ImmunoTherapy of Cancer 2015 3:40

    Published on: 20 October 2015

    The Erratum to this article has been published in Journal for ImmunoTherapy of Cancer 2015 3:56

  4. Research article

    Baseline circulating IL-17 predicts toxicity while TGF-β1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma

    We evaluated candidate circulating serum cytokines, chemokines and growth factors in patients with locally/regionally advanced melanoma receiving neoadjuvant ipilimumab with toxicity and clinical outcome.

    Ahmad A. Tarhini, Haris Zahoor, Yan Lin, Usha Malhotra, Cindy Sander, Lisa H. Butterfield and John M. Kirkwood

    Journal for ImmunoTherapy of Cancer 2015 3:39

    Published on: 15 September 2015

  5. Research article

    Increased CTLA-4+ T cells and an increased ratio of monocytes with loss of class II (CD14+ HLA-DRlo/neg) found in aggressive pediatric sarcoma patients

    There is little information regarding the composition of peripheral blood immunity in sarcoma patients and even less in the context of pediatric sarcomas. We describe the immune status using flow cytometry of ...

    Pooja Hingorani, Mary L. Maas, Michael P. Gustafson, Paul Dickman, Roberta H. Adams, Masayo Watanabe, Francis Eshun, James Williams, Matthew J. Seidel and Allan B. Dietz

    Journal for ImmunoTherapy of Cancer 2015 3:35

    Published on: 18 August 2015

  6. Short report

    Peripheral T cell receptor diversity is associated with clinical outcomes following ipilimumab treatment in metastatic melanoma

    Ipilimumab improves overall survival in a subset of patients with metastatic melanoma. Peripheral blood T cell receptor (TCR) repertoire diversity has been associated with favorable outcomes in patients with c...

    Michael A. Postow, Manuarii Manuel, Phillip Wong, Jianda Yuan, Zhiwan Dong, Cailian Liu, Solène Perez, Isabelle Tanneau, Marlène Noel, Anaïs Courtier, Nicolas Pasqual and Jedd D. Wolchok

    Journal for ImmunoTherapy of Cancer 2015 3:23

    Published on: 16 June 2015

  7. Commentary

    Preamble to the 2015 SITC immunotherapy biomarkers taskforce

    The Society for Immunotherapy of Cancer (SITC) has regularly hosted workshops and working groups focused on immunologic monitoring and immune biomarkers. Due to advances in cancer immunotherapy, including posi...

    Lisa H Butterfield, Mary L Disis, Bernard A Fox, Samir N Khleif and Francesco M Marincola

    Journal for ImmunoTherapy of Cancer 2015 3:8

    Published on: 24 March 2015

  8. Research article

    Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities

    We examined the phenotype and function of lymphocytes collected from the peripheral blood (PBL) and tumor (TIL) of patients with two different solid malignancies: colorectal cancer liver metastases (CRLM) and ...

    Magdalena Kovacsovics-Bankowski, Lana Chisholm, Jonna Vercellini, Christopher G Tucker, Ryan Montler, Daniel Haley, Philippa Newell, Jun Ma, Paul Tseng, Ronald Wolf, John T Vetto, Chet Hammill, Paul Hansen and Andrew D Weinberg

    Journal for ImmunoTherapy of Cancer 2014 2:38

    Published on: 18 November 2014

  9. Research article

    Immunoglobulin-like transcript 2 (ILT2) is a biomarker of therapeutic response to oncolytic immunotherapy with vaccinia viruses

    Oncolytic viruses represent a novel form of cancer immunotherapy. Vaccinia viruses encoding human T cell co-stimulatory molecules have demonstrated clinical activity in phase I clinical trials in patients with...

    Andrew Zloza, Dae Won Kim, Seunghee Kim-Schulze, Michael C Jagoda, Vladia Monsurro, Francesco M Marincola and Howard L Kaufman

    Journal for ImmunoTherapy of Cancer 2014 2:1

    Published on: 27 January 2014

  10. Research article

    Immune monitoring using the predictive power of immune profiles

    We have developed a novel approach to categorize immunity in patients that uses a combination of whole blood flow cytometry and hierarchical clustering.

    Michael P Gustafson, Yi Lin, Betsy LaPlant, Courtney J Liwski, Mary L Maas, Stacy C League, Philippe R Bauer, Roshini S Abraham, Matthew K Tollefson, Eugene D Kwon, Dennis A Gastineau and Allan B Dietz

    Journal for ImmunoTherapy of Cancer 2013 1:7

    Published on: 27 June 2013

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