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Reviews

Section edited by Sandra Demaria, MD and Thomas F. Gajewski, MD, PhD

Reviews are generally directly commissioned by JITC editors. These are fact/data-driven works that cumulate several articles of importance on a particular subject or research area in a review format with the goal of providing the “state of the art” in the field. Topics include recent major advances and discoveries, significant gaps in the research, current debates, and/or ideas of where research might go next written by authors who are leading contributors in the field. We do not encourage unsolicited submissions for this type of article. However, potential authors may send presubmission enquiries addressed to the section editors at JITCEditor@sitcancer.org for further consideration by JITC editorial leadership.

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  1. Content type: Review

    Management of small cell lung cancer (SCLC) has not changed over the last decades. In more recent years, alterations of DNA repair machinery and other molecular pathways have been identified in SCLC and precli...

    Authors: A. Pavan, I. Attili, G. Pasello, V. Guarneri, P. F. Conte and L. Bonanno

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:205

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  2. Content type: Review

    Tumor mutational burden (TMB), the total number of somatic coding mutations in a tumor, is emerging as a promising biomarker for immunotherapy response in cancer patients. TMB can be quantitated by a number of...

    Authors: Laura Fancello, Sara Gandini, Pier Giuseppe Pelicci and Luca Mazzarella

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:183

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  3. Content type: Review

    Tumor immunology has changed the landscape of cancer treatment. Yet, not all patients benefit as cancer immune responsiveness (CIR) remains a limitation in a considerable proportion of cases. The multifactorial d...

    Authors: Davide Bedognetti, Michele Ceccarelli, Lorenzo Galluzzi, Rongze Lu, Karolina Palucka, Josue Samayoa, Stefani Spranger, Sarah Warren, Kwok-Kin Wong, Elad Ziv, Diego Chowell, Lisa M. Coussens, Daniel D. De Carvalho, David G. DeNardo, Jérôme Galon, Howard L. Kaufman…

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:131

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    The Correction to this article has been published in Journal for ImmunoTherapy of Cancer 2019 7:167

  4. Content type: Review

    Dendritic cells (DCs) can initiate and direct adaptive immune responses. This ability is exploitable in DC vaccination strategies, in which DCs are educated ex vivo to present tumor antigens and are administer...

    Authors: Kalijn F. Bol, Gerty Schreibelt, Katrin Rabold, Stefanie K. Wculek, Julia Katharina Schwarze, Andrzej Dzionek, Alvaro Teijeira, Lana E. Kandalaft, Pedro Romero, George Coukos, Bart Neyns, David Sancho, Ignacio Melero and I. Jolanda M. de Vries

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:109

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  5. Content type: Review

    The activity of the commensal microbiota significantly impacts human health and has been linked to the development of many diseases, including cancer. Gnotobiotic animal models have shown that the microbiota h...

    Authors: Jessica Fessler, Vyara Matson and Thomas F. Gajewski

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:108

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  6. Content type: Review

    The increasing use of multiple immunomodulatory (IMD) agents for cancer therapies (e.g. antibodies targeting immune checkpoints, bispecific antibodies, and chimeric antigen receptor [CAR]-T cells), is raising ...

    Authors: Jasmine Davda, Paul Declerck, Siwen Hu-Lieskovan, Timothy P. Hickling, Ira A. Jacobs, Jeffrey Chou, Shahram Salek-Ardakani and Eugenia Kraynov

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:105

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  7. Content type: Review

    Growing evidence suggests a clear role of the host immune system in HER2+ breast cancer. In addition, HER2+ breast cancer is generally considered more immunogenic than hormone receptor-positive (HR+)/HER2-, an...

    Authors: Gaia Griguolo, Tomás Pascual, Maria Vittoria Dieci, Valentina Guarneri and Aleix Prat

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:90

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  8. Content type: Review

    Quantitative lymphocyte alterations are frequent in patients with cancer, and strongly impact prognosis and survival. The development of cancers in immunosuppressed patients has demonstrated the contribution o...

    Authors: Christine Ménétrier-Caux, Isabelle Ray-Coquard, Jean-Yves Blay and Christophe Caux

    Citation: Journal for ImmunoTherapy of Cancer 2019 7:85

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  9. Content type: Review

    Immunotherapy is at the forefront of modern oncologic care. Various novel therapies have targeted all three layers of tumor biology: tumor, niche, and immune system with a range of promising results. One emerg...

    Authors: Junaid Raja, Johannes M. Ludwig, Scott N. Gettinger, Kurt A. Schalper and Hyun S. Kim

    Citation: Journal for ImmunoTherapy of Cancer 2018 6:140

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  10. Content type: Review

    Chimeric Antigen Receptor (CAR) T cell therapies – adoptive T cell therapies that have been genetically engineered for a new antigen-specificity - have displayed significant success in treating patients with h...

    Authors: Michael M. Boyiadzis, Madhav V. Dhodapkar, Renier J. Brentjens, James N. Kochenderfer, Sattva S. Neelapu, Marcela V. Maus, David L. Porter, David G. Maloney, Stephan A. Grupp, Crystal L. Mackall, Carl H. June and Michael R. Bishop

    Citation: Journal for ImmunoTherapy of Cancer 2018 6:137

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  11. Content type: Review

    Escalating healthcare costs are necessitating the practice of value-based oncology. It is crucial to critically evaluate the economic impact of influential but expensive therapies such as immune checkpoint inh...

    Authors: Vivek Verma, Tanja Sprave, Waqar Haque, Charles B. Simone II, Joe Y. Chang, James W. Welsh and Charles R. Thomas Jr

    Citation: Journal for ImmunoTherapy of Cancer 2018 6:128

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  12. Content type: Review

    The treatment of metastatic melanoma patients with autologous tumor-infiltrating lymphocytes (TIL) shows robust, reproducible, clinical responses in clinical trials executed in several specialized centers over...

    Authors: Maartje W. Rohaan, Joost H. van den Berg, Pia Kvistborg and John B. A. G. Haanen

    Citation: Journal for ImmunoTherapy of Cancer 2018 6:102

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  13. Content type: Review

    CD8+ T lymphocytes are the major anti-tumor effector cells. Most cancer immunotherapeutic approaches seek to amplify cytotoxic T lymphocytes (CTL) specific to malignant cells. A recently identified subpopulation ...

    Authors: Fathia Mami-Chouaib, Charlotte Blanc, Stéphanie Corgnac, Sophie Hans, Ines Malenica, Clémence Granier, Isabelle Tihy and Eric Tartour

    Citation: Journal for ImmunoTherapy of Cancer 2018 6:87

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  14. Content type: Review

    Cancer surgery is necessary and life-saving. However, the majority of patients develop postoperative recurrence and metastasis, which are the main causes of cancer-related deaths. The postoperative stress resp...

    Authors: Orneala Bakos, Christine Lawson, Samuel Rouleau and Lee-Hwa Tai

    Citation: Journal for ImmunoTherapy of Cancer 2018 6:86

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  15. Content type: Review

    Recent advances in our understanding of the dynamics of cellular cross-talk have highlighted the significance of host-versus-tumor effect that can be harnessed with immune therapies. Tumors exploit immune chec...

    Authors: Muhammad Umair Mushtaq, Athanasios Papadas, Adam Pagenkopf, Evan Flietner, Zachary Morrow, Sibgha Gull Chaudhary and Fotis Asimakopoulos

    Citation: Journal for ImmunoTherapy of Cancer 2018 6:65

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  16. Content type: Review

    During the last decade the field of cancer immunotherapy has witnessed impressive progress. Highly effective immunotherapies such as immune checkpoint inhibition, and T-cell engaging therapies like bispecific ...

    Authors: Alexander Shimabukuro-Vornhagen, Philipp Gödel, Marion Subklewe, Hans Joachim Stemmler, Hans Anton Schlößer, Max Schlaak, Matthias Kochanek, Boris Böll and Michael S. von Bergwelt-Baildon

    Citation: Journal for ImmunoTherapy of Cancer 2018 6:56

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  17. Content type: Review

    Several inhibitors of programmed cell death-1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved as a form of immunotherapy for multiple cancers. Ionizing radiation therapy (RT) has been shown to ...

    Authors: Jun Gong, Thang Q. Le, Erminia Massarelli, Andrew E. Hendifar and Richard Tuli

    Citation: Journal for ImmunoTherapy of Cancer 2018 6:46

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  18. Content type: Review

    Immunotherapy is among the most rapidly evolving treatment strategies in oncology. The therapeutic potential of immune-checkpoint inhibitors is exemplified by the recent hail of Food and Drug Administration (F...

    Authors: Young Kwang Chae, Ayush Arya, Wade Iams, Marcelo R. Cruz, Sunandana Chandra, Jaehyuk Choi and Francis Giles

    Citation: Journal for ImmunoTherapy of Cancer 2018 6:39

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  19. Content type: Review

    Immune checkpoint inhibitors targeting the PD-1 pathway have greatly changed clinical management of metastatic urothelial carcinoma and metastatic renal cell carcinoma. However, response rates are low, and bio...

    Authors: Jason Zhu, Andrew J. Armstrong, Terence W. Friedlander, Won Kim, Sumanta K. Pal, Daniel J. George and Tian Zhang

    Citation: Journal for ImmunoTherapy of Cancer 2018 6:4

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  20. Content type: Review

    Treatment options for metastatic urothelial carcinoma (mUC) remained relative unchanged over the last 30 years with combination chemotherapy as the mainstay of treatment. Within the last year the landscape for...

    Authors: David H. Aggen and Charles G. Drake

    Citation: Journal for ImmunoTherapy of Cancer 2017 5:94

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  21. Content type: Review

    With the approval of talimogene laherparepvec (T-VEC) for inoperable locally advanced or metastatic malignant melanoma in the USA and Europe, oncolytic virotherapy is now emerging as a viable therapeutic optio...

    Authors: Adam Ajina and John Maher

    Citation: Journal for ImmunoTherapy of Cancer 2017 5:90

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  22. Content type: Review

    Metastatic disease is the leading cause of death among cancer patients and involves a complex and inefficient process. Every step of the metastatic process can be rate limiting and is influenced by non-maligna...

    Authors: Louise M.E. Janssen, Emma E. Ramsay, Craig D. Logsdon and Willem W. Overwijk

    Citation: Journal for ImmunoTherapy of Cancer 2017 5:79

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  23. Content type: Review

    The use of immunomodulation to treat malignancies has seen a recent explosion in interest. The therapeutic appeal of these treatments is far reaching, and many new applications continue to evolve. In particula...

    Authors: Ryan Slovak, Johannes M. Ludwig, Scott N. Gettinger, Roy S. Herbst and Hyun S. Kim

    Citation: Journal for ImmunoTherapy of Cancer 2017 5:78

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  24. Content type: Meeting report

    Understanding how murine models can elucidate the mechanisms underlying antitumor immune responses and advance immune-based drug development is essential to advancing the field of cancer immunotherapy. The Soc...

    Authors: Andrew Zloza, A. Karolina Palucka, Lisa M. Coussens, Philip J. Gotwals, Mark B. Headley, Elizabeth M. Jaffee, Amanda W. Lund, Arlene H. Sharpe, Mario Sznol, Derek A. Wainwright, Kwok-Kin Wong and Marcus W. Bosenberg

    Citation: Journal for ImmunoTherapy of Cancer 2017 5:77

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  25. Content type: Review

    Therapeutic efforts to engage the immune system against cancer have yielded exciting breakthroughs and a growing list of approved immune-based agents across a variety of disease states. Despite the early succe...

    Authors: James L. Gulley, Elizabeth A. Repasky, Laura S. Wood and Lisa H. Butterfield

    Citation: Journal for ImmunoTherapy of Cancer 2017 5:55

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  26. Content type: Review

    The tumor-permissive and immunosuppressive characteristics of tumor-associated macrophages (TAM) have fueled interest in therapeutically targeting these cells. In this context, the colony-stimulating factor 1 ...

    Authors: Michael A. Cannarile, Martin Weisser, Wolfgang Jacob, Anna-Maria Jegg, Carola H. Ries and Dominik Rüttinger

    Citation: Journal for ImmunoTherapy of Cancer 2017 5:53

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  27. Content type: Review

    This report is a summary of ‘New Cancer Immunotherapy Agents in Development’ program, which took place in association with the 31st Annual Meeting of the Society for Immunotherapy of Cancer (SITC), on November...

    Authors: Prasad S. Adusumilli, Edward Cha, Mark Cornfeld, Thomas Davis, Adi Diab, Thomas W. Dubensky Jr., Elizabeth Evans, Jane L. Grogan, Bryan A. Irving, Rom S. Leidner, Shane A. Olwill, Patrick Soon-Shiong, Frederic Triebel, David Tuck, Adrian Bot, Roger D. Dansey…

    Citation: Journal for ImmunoTherapy of Cancer 2017 5:50

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  28. Content type: Review

    As cancer strikes, individuals vary not only in terms of factors that contribute to its occurrence and development, but as importantly, in their capacity to respond to treatment. While exciting new therapeutic...

    Authors: Sacha Gnjatic, Vincenzo Bronte, Laura Rosa Brunet, Marcus O. Butler, Mary L. Disis, Jérôme Galon, Leif G. Hakansson, Brent A. Hanks, Vaios Karanikas, Samir N. Khleif, John M. Kirkwood, Lance D. Miller, Dolores J. Schendel, Isabelle Tanneau, Jon M. Wigginton and Lisa H. Butterfield

    Citation: Journal for ImmunoTherapy of Cancer 2017 5:44

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  29. Content type: Review

    Cancer immunotherapies are showing promising clinical results in a variety of malignancies. Monitoring the immune as well as the tumor response following these therapies has led to significant advancements in ...

    Authors: David F. Stroncek, Lisa H. Butterfield, Michael A. Cannarile, Madhav V. Dhodapkar, Tim F. Greten, Jean Charles Grivel, David R. Kaufman, Heidi H. Kong, Firouzeh Korangy, Peter P. Lee, Francesco Marincola, Sergio Rutella, Janet C. Siebert, Giorgio Trinchieri and Barbara Seliger

    Citation: Journal for ImmunoTherapy of Cancer 2017 5:21

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  30. Content type: Review

    Cancer immunotherapy and in particular monoclonal antibodies blocking the inhibitory programed cell death 1 pathway (PD-1/PD-L1) have made a significant impact on the treatment of cancer patients in recent yea...

    Authors: Patrick A. Ott, F. Stephen Hodi, Howard L. Kaufman, Jon M. Wigginton and Jedd D. Wolchok

    Citation: Journal for ImmunoTherapy of Cancer 2017 5:16

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  31. Content type: Review

    Established tumors build a stressful and hostile microenvironment that blocks the development of protective innate and adaptive immune responses. Different subsets of immunoregulatory myeloid populations, incl...

    Authors: Juan R. Cubillos-Ruiz, Eslam Mohamed and Paulo C. Rodriguez

    Citation: Journal for ImmunoTherapy of Cancer 2017 5:5

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  32. Content type: Review

    Despite recent major clinical breakthroughs in human cancer immunotherapy including the use of checkpoint inhibitors and engineered T cells, important challenges remain, including determining the sub-populatio...

    Authors: Jiwon S. Park, Sita S. Withers, Jaime F. Modiano, Michael S. Kent, Mingyi Chen, Jesus I. Luna, William T. N. Culp, Ellen E. Sparger, Robert B. Rebhun, Arta M. Monjazeb, William J. Murphy and Robert J. Canter

    Citation: Journal for ImmunoTherapy of Cancer 2016 4:97

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  33. Content type: Review

    Cancer therapies based on T cells have shown impressive clinical benefit. In particular, immune checkpoint blockade therapies with anti-CTLA-4 and anti-PD-1/PD-L1 are causing dramatic tumor shrinkage and prolo...

    Authors: Hiep Khong and Willem W. Overwijk

    Citation: Journal for ImmunoTherapy of Cancer 2016 4:56

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  34. Content type: Meeting report

    Treatment strategies that target the immune system provide the opportunity for antitumor activity across multiple cancer types, regardless of mutational status or tumor histology. While many of the initial adv...

    Authors: Paolo Antonio Ascierto, Giacomo Cartenì, Cesare Gridelli, Sandro Pignata, Antonio Pinto, Carmen Criscitiello, Luigi Buonaguro, Stefano Pepe, Roberto Mabilia, Vincenzo Montesarchio, Bruno Daniele and Sabino De Placido

    Citation: Journal for ImmunoTherapy of Cancer 2016 4:41

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  35. Content type: Review

    The efficacy of PD-1/PD-L1 targeted therapies in addition to anti-CTLA-4 solidifies immunotherapy as a modality to add to the anticancer arsenal. Despite raising the bar of clinical efficacy, immunologically t...

    Authors: Holbrook E. Kohrt, Paul C. Tumeh, Don Benson, Nina Bhardwaj, Joshua Brody, Silvia Formenti, Bernard A. Fox, Jerome Galon, Carl H. June, Michael Kalos, Ilan Kirsch, Thomas Kleen, Guido Kroemer, Lewis Lanier, Ron Levy, H. Kim Lyerly…

    Citation: Journal for ImmunoTherapy of Cancer 2016 4:15

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  36. Content type: Review

    The culmination of over a century’s work to understand the role of the immune system in tumor control has led to the recent advances in cancer immunotherapies that have resulted in durable clinical responses i...

    Authors: Jianda Yuan, Priti S. Hegde, Raphael Clynes, Periklis G. Foukas, Alexandre Harari, Thomas O. Kleen, Pia Kvistborg, Cristina Maccalli, Holden T. Maecker, David B. Page, Harlan Robins, Wenru Song, Edward C. Stack, Ena Wang, Theresa L. Whiteside, Yingdong Zhao…

    Citation: Journal for ImmunoTherapy of Cancer 2016 4:3

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  37. Content type: Meeting report

    In this paper, we review recent advances in immuno-oncology with particular focus on liver, kidney, and bladder cancers as discussed at the 2nd meeting of the Campania Society of Oncology Immunotherapy (SCITO).

    Authors: Bruno Daniele, Bruno Sangro, Daniel Petrylak, Fabio Calabrò, Giacomo Cartenì, Vincenzo Montesarchio, Sabino De Placido and Paolo A. Ascierto

    Citation: Journal for ImmunoTherapy of Cancer 2016 4:1

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  38. Content type: Review

    Tumor cells escape the immune surveillance system of the host through a process called immune tolerance. Immunotherapy targets molecules that serve as checks and balances in the regulation of immune response. ...

    Authors: Yong Wha Moon, Joud Hajjar, Patrick Hwu and Aung Naing

    Citation: Journal for ImmunoTherapy of Cancer 2015 3:51

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  39. Content type: Meeting report

    The remarkable clinical success of cancer immunotherapies targeting the checkpoint receptors CTLA-4 and PD-1 has generated considerable excitement and emboldened efforts to build on this important foundation. ...

    Authors: Abigail E. Overacre, Sema Kurtulus, Mario Sznol, Drew M. Pardoll, Ana Anderson and Dario A. A. Vignali

    Citation: Journal for ImmunoTherapy of Cancer 2015 3:38

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  40. Content type: Review

    The development of the cytotoxic T-lymphocyte-associated protein 4 inhibitor ipilimumab and its approval in 2011 for the treatment of metastatic melanoma has heralded a new era in immuno-oncology. Subsequently...

    Authors: Leila Khoja, Marcus O. Butler, S. Peter Kang, Scot Ebbinghaus and Anthony M. Joshua

    Citation: Journal for ImmunoTherapy of Cancer 2015 3:36

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