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  1. Content type: Poster presentation

    Authors: Michelle Krogsgaard, Shi Zhong, Karolina Malecek, Laura A Johnson, Zhiya Yu, Eleazar Vega-Saenz de Miera, Farbod Darvishian, Katelyn McGary-Shipper, Kevin Huang, Joshua Boyer, Emily Corse, Yongzhao Shao, Steven A Rosenberg, Nicholas P Restifo and Iman Osman

    Citation: Journal for ImmunoTherapy of Cancer 2013 1(Suppl 1):P242

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    This article is part of a Supplement: Volume 1 Supplement 1

  2. Content type: Poster presentation

    Authors: Michele Sommariva, Foo Cheung, Jinguo Chen, Rongye Shi, Ling Zhang, Richard Morgan, Davide Bedognetti, Valeria De Giorgi, Maria L Ascierto, Steven A Rosenberg, Francesco M Marincola and Ena Wang

    Citation: Journal for ImmunoTherapy of Cancer 2013 1(Suppl 1):P63

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    This article is part of a Supplement: Volume 1 Supplement 1

  3. Content type: Oral presentation

    Authors: Meredith Leong, David Kanne, Laura Glickman, Edward Lemmens, Peter Lauer, Ken Metchette, Dara Burdette, Elie Diner, Juan Fu, Kevin Soares, Dirk Brockstedt, Daniel Portnoy, Russell Vance, Young Kim, Elizabeth Jaffee, Drew Pardoll…

    Citation: Journal for ImmunoTherapy of Cancer 2013 1(Suppl 1):O20

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    This article is part of a Supplement: Volume 1 Supplement 1

  4. Content type: Research article

    The development of immuno-oncologic agents poses unique challenges, namely that both efficacy and safety profiles differ from previously characterized cytotoxic and pathway-specific agents. In addition, expone...

    Authors: Tai-Tsang Chen

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:18

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  5. Content type: Research article

    Sub-lethal doses of radiation can alter the phenotype of target tissue by modulating gene expression and making tumor cells more susceptible to T-cell-mediated immune attack. We have previously shown that sub-...

    Authors: Anita Kumari, Ercan Cacan, Susanna F Greer and Charlie Garnett-Benson

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:17

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  6. Content type: Research article

    One of the significant tumor immune escape mechanisms and substantial barrier for successful immunotherapy is tumor-mediated inhibition of immune response through cell-to-cell or receptor/ligand interactions. ...

    Authors: Mikayel Mkrtichyan, Namju Chong, Rasha Abu Eid, Anu Wallecha, Reshma Singh, John Rothman and Samir N Khleif

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:15

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  7. Content type: Research article

    Molecular imaging with positron emission tomography (PET) may allow the non-invasive study of the pharmacodynamic effects of agonistic monoclonal antibodies (mAb) to 4-1BB (CD137). 4-1BB is a member of the tum...

    Authors: Helena Escuin-Ordinas, Mark W Elliott, Mohammad Atefi, Michelle Lee, Charles Ng, Liu Wei, Begoña Comin-Anduix, Encarnacion Montecino-Rodriguez, Earl Avramis, Caius Radu, Leslie L Sharp and Antoni Ribas

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:14

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  8. Content type: Review

    Individualized cancer therapy is a central goal of cancer biologists. Immunotherapy is a rational means to this end—because the immune system can recognize a virtually limitless number of antigens secondary to...

    Authors: Timothy J Harris and Charles G Drake

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:12

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  9. Content type: Review

    T cells can mediate remarkable tumor regressions including complete cure in patients with metastatic cancer. Genetic alterations in an individual’s cancer cells (the mutanome) encode unique peptides (m-peptide...

    Authors: Willem W Overwijk, Ena Wang, Francesco M Marincola, Hans-Georg Rammensee and Nicholas P Restifo

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:11

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  10. Content type: Review

    Myeloid Derived Suppressor Cells (MDSC) are a heterogeneous population of immature myeloid cells that are increased in states of cancer, inflammation and infection. In malignant states, MDSC are induced by tum...

    Authors: Robert Wesolowski, Joseph Markowitz and William E Carson III

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:10

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  11. Content type: Research article

    CEA is expressed in >90% of pancreatic cancers (PC) and may be an appropriate immunotherapy target. CEA is poorly immunogenic due to immune tolerance; CAP1-6D, an altered peptide ligand can help bypass toleran...

    Authors: Daniel M Geynisman, Yuanyuan Zha, Rangesh Kunnavakkam, Mebea Aklilu, Daniel VT Catenacci, Blase N Polite, Cara Rosenbaum, Azadeh Namakydoust, Theodore Karrison, Thomas F Gajewski and Hedy L Kindler

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:8

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  12. Content type: Meeting report

    The Workshop associated with the 27th Annual Meeting of the Society for Immunotherapy of Cancer (SITC), North Bethesda, MD, October 24-25, 2012 focused on targeting the tumor microenvironment as part of an int...

    Authors: Melek Erdinc Sunay, Francesco Marincola, Samir N Khleif, Samuel C Silverstein, Bernard A Fox, Jerome Galon and Leisha A Emens

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:9

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  13. Content type: Research article

    We have developed a novel approach to categorize immunity in patients that uses a combination of whole blood flow cytometry and hierarchical clustering.

    Authors: Michael P Gustafson, Yi Lin, Betsy LaPlant, Courtney J Liwski, Mary L Maas, Stacy C League, Philippe R Bauer, Roshini S Abraham, Matthew K Tollefson, Eugene D Kwon, Dennis A Gastineau and Allan B Dietz

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:7

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  14. Content type: Meeting report

    The Society for Immunotherapy of Cancer (SITC) 2012 Professional Development Session was held as part of the SITC 27th Annual Meeting, Washington, DC, on October 24, 2012. The session was designed as a new opp...

    Authors: Christian M Capitini, William L Redmond and Kimberly A Shafer-Weaver

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:6

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  15. Content type: Meeting report

    The 27th annual meeting of the Society for Immunotherapy of Cancer (SITC) was held on October 26–28, 2012 in North Bethesda, Maryland and the highlights of the meeting are summarized. The topics covered at this m...

    Authors: David F Stroncek, Cornelis JM Melief, Luciano Castiello, Alessandra Cesano, Martin A Cheever, Sara Civini, Begonya Comin-Anduix, Thomas F Gajewski, Philip D Greenberg, Pawel Kalinski, Howard L Kaufman, Michael H Kershaw, Samir N Khleif, Francesco Marincola, William Merritt, David H Munn…

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:4

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  16. Content type: Research article

    Antigen-specific anti-tumor vaccines have demonstrated clinical efficacy, but immunological and clinical responses appear to be patient-dependent. We hypothesized that naturally-occurring differences in amino ...

    Authors: Jordan T Becker and Douglas G McNeel

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:2

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  17. Content type: Review

    Immunotherapeutics include drugs and biologics that render therapeutic benefit by harnessing the power of the immune system. The promise of immune-mediated therapies is target specificity with a consequent red...

    Authors: Ramjay S Vatsan, Peter F Bross, Ke Liu, Marc Theoret, Angelo R De Claro, Jinhua Lu, Whitney Helms, Brian Niland, Syed R Husain and Raj K Puri

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:5

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  18. Content type: Short report

    Treatment with agonist anti-CD137 (4-1BB) immunostimulatory monoclonal antibodies elicits complete tumor regressions in a number of transplanted hematological and solid malignancies in mice. Rejection is mainl...

    Authors: Aizea Morales-Kastresana, Elena Catalán, Sandra Hervás-Stubbs, Asis Palazón, Arantza Azpilikueta, Elixabet Bolaños, Alberto Anel, Julián Pardo and Ignacio Melero

    Citation: Journal for ImmunoTherapy of Cancer 2013 1:3

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