https://jitc.biomedcentral.com/articles/10.1186/2051-1426-2-22
https://jitc.biomedcentral.com/articles/10.1186/2051-1426-2-24
https://jitc.biomedcentral.com/articles/10.1186/2051-1426-2-21
https://jitc.biomedcentral.com/articles/10.1186/2051-1426-2-23