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Fig. 2 | Journal for ImmunoTherapy of Cancer

Fig. 2

From: Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment

Fig. 2

CB-1158 has favorable pharmacokinetic and pharmacodynamic properties in vivo with no overt signs of toxicity. LLC tumor-bearing mice (N = 5 per group) were administered a single dose of CB-1158 (a) or 5 twice-daily doses (b) and samples were collected 2 h after the last dose. CB-1158 and L-arginine in plasma and tumor lysates were measured by LC/MS. c Body weights of mice inoculated with CT26 cells and dosed with vehicle or CB-1158 twice daily for 23 days. (**** P < 0.0001; *** P < 0.001; ** P < 0.01 vs. vehicle)

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