Fig. 2
![Fig. 2](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs40425-017-0308-4/MediaObjects/40425_2017_308_Fig2_HTML.gif)
CB-1158 has favorable pharmacokinetic and pharmacodynamic properties in vivo with no overt signs of toxicity. LLC tumor-bearing mice (N = 5 per group) were administered a single dose of CB-1158 (a) or 5 twice-daily doses (b) and samples were collected 2 h after the last dose. CB-1158 and L-arginine in plasma and tumor lysates were measured by LC/MS. c Body weights of mice inoculated with CT26 cells and dosed with vehicle or CB-1158 twice daily for 23 days. (**** P < 0.0001; *** P < 0.001; ** P < 0.01 vs. vehicle)