Skip to main content
Download PDF

Granulomatous/sarcoid-like lesions associated with checkpoint inhibitors: a marker of therapy response in a subset of melanoma patients

Journal for ImmunoTherapy of Cancer volume 6, Article number: 14 (2018) Cite this article

Abstract

Background

Immune checkpoint therapy has dramatically changed the landscape of cancer therapy, providing an efficacious and durable therapeutic option for patients with advanced-stage disease. However, dermatologic toxicities are a well-recognized side effect in patients receiving this therapy. A spectrum of immune related adverse events (irAEs) involving the skin can occur and include immunobullous disorders, lichenoid dermatitis, and vitiligo. Granulomatous/sarcoid-like lesions are now being recognized with the current class of checkpoint inhibitors (CPIs) that involve the dermis, the subcutaneous tissue (panniculitis), and lymph nodes.

Case presentation

We report 3 patients who developed granulomatous/sarcoid-like lesions while being treated with immune checkpoint therapy for advanced-stage melanoma, and we provide a comprehensive review of the literature in which similar cases are described. To date, 26 patients (including the 3 from this report) have been described with a median age of 57 years who developed granulomatous/sarcoid-like lesions associated with CPIs (median onset 6 months), of which 77% of patients had melanoma as primary tumor. To manage this adverse side effect, therapy was withheld in 38% of patients and 44% of the patients were treated with systemic steroids and 8% patients with localized therapy (one patient with intralesional triamcinolone). 96% of patients demonstrated either resolution or improvement of granulomatous/sarcoid-like lesions associated with CPIs irrespective of medical intervention. Therapeutic response, stable disease, or remission of primary malignancy was observed in 71% of reported patients who developed granulomatous/sarcoid-like lesions associated with CPIs over a median follow-up of 11.5 months since initiation of treatment.

Conclusions

The development of granulomatous/sarcoid-like lesions associated with CPIs is a recognized manifestation with the current class of immune checkpoint therapy that may clinically and radiographically mimic disease recurrence. Awareness of this type of toxicity is important for appropriate management and possible measurement of therapeutic response in a subset of patients who manifest this type of immune-mediated reaction.

Background

Immune checkpoint inhibitors (such as ipilimumab, nivolumab and pembrolizumab) are novel monoclonal antibodies that target cytotoxic T-lymphocyte–associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) cell signaling, respectively and attempt to restore patients’ anti-tumor T-cell response that may be endogenously diminished as part of tumor escape mechanisms. Inclusion of immune checkpoint inhibitors in the armamentarium to battle cancer has broadened the landscape of cancer therapy since their use can elicit clinically efficacious and durable anti-tumor immune response [1, 2].

Cancer patients receiving immune checkpoint inhibitors are prone to develop immune-related adverse events (irAEs); a common and early site of involvement includes the skin [3]. The types of dermatologic toxicities are diverse and include dermal hypersensitivity reactions, lichenoid eruptions, and immunobullous reactions and may become sufficiently severe to require cessation of further treatment [4,5,6]. Granulomatous/sarcoid-like lesions are a recognized toxicity associated with the current class of therapy with checkpoint inhibitors (CPIs) that can involve the dermis and subcutis (erythema nodosum-like panniculitis) [7,8,9,10,11]. Granulomatous/sarcoid-like lesions associated with CPIs are significant because they often mimic disease recurrence and/or consequently lead to cessation of therapy, adding further challenges to the management of adverse immune-related events.

Systemic sarcoidosis is a multi-organ disease of unknown etiology in which there is collection of epithelioid immune cells in the form of granulomata in affected tissue [12]. Sarcoidal granulomata are frequently located in the lungs, lymph nodes, cardiovascular sites, central nervous system, and the skin [13]. Pulmonary granulomata and hilar lymphadenopathy (LAD) may be seen in 90% of patients with sarcoidosis [13]. A diagnosis of sarcoidosis requires demonstration of the characteristic granulomata on tissue biopsy, and/or by a constellation of clinical symptoms, including fever, fatigue, shortness of breath and weight loss, which may indicate specific organ involvement [12]. Granulomatous/sarcoid-like lesions associated with CPIs may exhibit histopathologic features of “sarocoidal” granulomas and may represent reactions to therapy [14].

We report 3 patients who manifested clinical and radiographic features of granulomatous/sarcoid-like lesions associated CPIs. Awareness of this toxicity from the current class of CPI will be critical for appropriate diagnosis and patient management.

Case presentation

Patient 1

A 79-year-old man with stage IV M1C NRAS Q61K-mutant metastatic melanoma from an ulcerated primary lesion on the chest (Breslow thickness, not available due to tangential sections, Clark level IV, 26 mitotic figures/mm2), and metastasis to 1 of 40 regional lymph nodes without extracapsular extension, demonstrated an enlarging right lung nodule 8 months after his initial diagnosis. Given concern for disease progression, he completed 4 doses of ipilimumab without evidence of therapeutic response. He had no history of autoimmune disease. Past medical history included type 2 diabetes mellitus, hypertension, and mixed hyperlipidemia.

Six months after completion of ipilimumab therapy, surveillance studies revealed interval progression of disease with new bilateral pulmonary nodules, mediastinal and hilar lymphadenopathy, a liver lesion, and an adrenal nodule, suggestive of metastatic melanoma. Pembrolizumab therapy (2 mg/kg) was subsequently initiated, and computed tomography (CT) scans 3 months after initiation of pembrolizumab revealed radiographic improvement and decreased size of pulmonary, liver, and adrenal lesions. The patient tolerated 22 cycles of pembrolizumab with minimal adverse reactions, and CT scans obtained 15 months after initiation of therapy revealed stable disease without new lesions. Restaging positron emission tomography/CT (PET/CT) scans obtained 18 months after initiation of pembrolizumab therapy revealed enlarging gastric, retroperitoneal, and paratracheal lymph nodes, and after 20 months of pembrolizumab therapy (27 cycles), the patient presented with erythema and swelling of the forearms. Physical examination revealed symmetrical, firm subcutaneous nodules involving bilateral dorsal hands, forearms, and elbows (Fig. 1a-b). Ultrasound examination revealed a 4.3 × 1 × 2.3 cm soft tissue nodule (Fig. 1c), and needle core and skin punch biopsies showed a collection of epithelioid histiocytes forming non-caseating granulomata (Fig. 1d-e). Fite, Gomori methenamine silver, and gram stains and tissue cultures were negative for microorganisms. Melanoma was not identified. PET/CT performed at 23 months of pembrolizumab therapy (30 cycles), revealed prominent fluorodeoxyglucose (FDG) avidity of mediastinal / bilateral hilar LAD and subcutaneous nodules (Fig. 1f). In view of the clinical, radiographic, and histologic findings, these features were consistent with a cutaneous granulomatous/sarcoid-like lesions associated with CPI involving the skin and pulmonary lymph nodes. Given the patient’s excellent response to pembrolizumab therapy and the development of these therapy related granulomatous/sarcoid-like lesions, his therapy was subsequently discontinued.

Fig. 1
figure 1

Patient 1. Multiple soft tissue nodules on the a wrist (arrows) and b forearm (arrows). c Ultrasound of wrist with a nodular plaque. d Biopsy of nodule with non-caseating granulomata in the dermis and subcutis composed of a collection of epithelioid histiocytes (hematoxylin and eosin [H&E] original magnification × 40). e Granulomata with multinucleated giant cells (H&E original magnification × 400). f PET/CET with FDG avid bilateral hilar and mediastinal lymph nodes

Full size image

Follow up examination at 2 months demonstrated persistence of skin nodules and intralesional triamcinolone was initiated. Restaging studies at this time demonstrated stable LAD and no evidence of melanoma disease progression. One month later, intralesional injection demonstrated interval softening and decreased diameter of the cutaneous nodules.

Patient 2

A 44-year-old woman with stage IIIB metastatic melanoma from the chest (Clark level IV, Breslow thickness of 0.37 mm, and mitotic rate of 1/mm2) with synchronous metastasis to 1 of 23 regional lymph nodes began ipilimumab therapy (3 mg/kg) in the adjuvant setting. The patient completed 4 cycles of ipilimumab with no adverse reactions. Imaging studies after completion of the 4 doses revealed new, nonspecific, metabolically active mediastinal and bilateral hilar LAD that appeared reactive, and clinical surveillance was continued. Three months after completing ipilimumab therapy, imaging studies revealed enlarged, FDG avid mediastinal and bilateral hilar lymph nodes (Fig. 2a-b) and small FDG avid foci in subcutaneous tissue of both lower extremities. Physical examination revealed 4 small palpable subcutaneous nodules of the bilateral peri-patellar skin, and histologic evaluation demonstrated a collection of epithelioid histiocytes in the subcutis, forming multiple granulomatous/sarcoid-like lesions associated with CPIs (Fig. 2c-d). Past medical history included hypothyroidism, hypertension, and partial hysterectomy. There was no history of an autoimmune disorder.

Fig. 2
figure 2

Patient 2. a Axial and b coronal views of PET/CT with FDG avid bilateral hilar and mediastinal lymph nodes. c Skin biopsy with epithelioid granulomata in the subcutaneous tissue (*) (H&E, original magnification × 20). d Collection of epithelioid histiocytes with surrounding lymphocytes inflammation forming non-caseating granulomata lacking caseating necrosis (H&E, original magnification × 400)

Full size image

Eight months after completing ipilimumab, CT examination demonstrated interval reduction in the size of the mediastinal and hilar lymph nodes and no evidence of disease progression. On dermatologic examination, the peri-patellar skin lesions demonstrated complete resolution with no specific intervention.

Patient 3

A 68-year-old man with stage IV M1c metastatic NRAS G13D, CDKN2A, and TP53 mutant, ulcerated lentigo maligna melanoma from the neck (Clark level IV, Breslow thickness 2.5 mm, mitotic rate of 16/mm2) developed disease recurrence in 1 of 17 ipsilateral neck lymph nodes without extracapsular extension 8 months after wide local excision and one negative sentinel lymph node biopsy. One and 3 months after disease recurrence, imaging studies revealed distant metastases to right proximal humerus and soft tissue (9.5 cm) and temporal lobe of brain, respectively. Pembrolizumab therapy (2 mg/kg) was initiated, and stereotactic radiosurgery with a gamma knife was performed on the solitary brain metastasis. After 6 months (9 doses) of pembrolizumab, the patient developed new hypermetabolic hilar and mediastinal lymph nodes (the largest measured 1.6 cm) on PET/CT (Fig. 3a-b) at the site of a non-tumor draining lymph node basin. These hilar and mediastinal lymph nodes were inconspicuous radiographically prior to pembrolizumab therapy, but developed only during the course of pembrolizumab therapy. Ultrasound-guided endobronchial fine needle aspiration (FNA) biopsy of targeted, hypermetabolic lymph nodes (subcarinal Station 7 and lower paratracheal 4R) were negative for melanoma (Fig. 3c). Instead, examination of FNA revealed these lymph nodes were reactive; containing clusters of epitheilioid histiocytes with pigmented macrophages. Restaging scans after 8 months of pembrolizumab therapy (13 doses) revealed resolution of PET avid mediastinal lymph nodes and no evidence of disease (Fig. 3d-e). Taken together, the clinical and radiographic presentation along with our prior experience was most compatible with granulomatous/sarcoid-like lesions associated with CPIs. Past medical history include non-melanocytic skin cancers. There was no history of an autoimmune disorder.

Fig. 3
figure 3

Patient 3. a Axial and b coronal views of PET/CT with FDG-avid hilar and mediastinal lymph nodes. c Axial and d coronal views of PET/CT with resolution of FDG-avid hilar and mediastinal lymph nodes after 18 months of immune checkpoint therapy. e Ultrasound guided endobronchial fine needle aspiration biopsy was negative for melanoma and revealed cluster of reactive epithelioid histiocytes, some with anthracotic pigmented macrophages (*), admixed with scattered lymphocytes (Papanicolaou stain, original magnification × 40)

Full size image

After nearly 2 years of pembrolizumab therapy (32 doses), there was no evidence of disease progression.

Discussion and conclusions

Granulomatous/sarcoid-like lesions associated with CPIs may be clinically and radiographically concerning for disease recurrence and may significantly impact patient treatment [8, 9, 11]. Recognition and appropriate treatment of such toxicities resulting from immune checkpoint therapy are critical for optimal patient care. To date, a comprehensive review of the literature identified 26 patients (including 3 from this report) with a median age of 57 years (range: 26-79 years) who developed granulomatous/sarcoid-like lesions (n = 23, sarcoidosis-like reactions; n = 3, granulomatous panniculitis) associated with CPIs (ipilimumab = 14; nivolumab = 3; pembrolizumab = 5; anti-PD-L1 = 1; combined ipilimumab + nivolumab = 3) (Table 1) [7,8,9,10,11, 15,16,17,18,19,20,21,22,23,24,25,26,27,28,29]. There was slight female predominance (M:F ratio 11:13), and melanoma accounted for 77% of the primary tumors treated with immune checkpoint therapy. Interestingly, hypothyroidism was seen in a subset of patients with granulomatous/sarcoid-like lesions associated with CPIs. Sites most frequently involved by sarcoidosis include the lung, hilar and mediastinal lymph nodes, and/or skin (in 79% of cases). There were 4 patients with granulomatous/sarcoid-like lesions associated with CPIs were limited to the skin, including 3 patients with granulomatous panniculitis, of which, 2 had no clinical and radiographic features of LAD. The median duration of immune checkpoint therapy was 6 months (range: 0.75-20 months) in patients that developed granulomatous/sarcoid-like lesions associated with CPIs. Treatment for the granulomatous/sarcoid-like lesions associated with CPIs included withholding therapy in 38% of patients and/or administration of systemic steroids in 44% of patients. Either resolution or improvement of these immune-mediated reactions occurred in 96% of reported patients irrespective of how the toxicity was managed. Partial therapeutic response, stable disease, or complete remission of malignancy was observed in 71% of reported patients who developed granulomatous/sarcoid-like lesions associated with CPIs over a median follow-up of 11.5 months (range: 3-54 months) since initiation of treatment. Disease progression was observed in 29% of reported patients with granulomatous/sarcoid-like lesions associated with CPIs. Follow up was not available for 2 patients.

Table 1 Granulomatous/sarcoid-like lesions associated with checkpoint inhibitors
Full size table

Patients with prolonged chronic inflammation and immune dysfunction have increased risk of developing, lymphomas, melanomas and other solid tumors as well as sarcoidosis [14, 30]. Furthermore, cancer patients with sarcoidosis have higher incidence of melanoma, hematolymphoid, gastrointestinal, and other solid tumors [14]. However, activation of T-cell response with CPI therapy has improved survival in a subset of patients with these types of malignancies. In addition, it appears a subset of patients who develop granulomatous/sarcoid-like lesions during CPI therapy exhibit favorable therapeutic response. Therefore, the balance of T-cell activation and type of T helper (Th) response appears complex.

Cancer therapy associated granulomatous/sarcoid-like lesions is not unique to immune checkpoint therapy and has been described in a variety of patients with hematologic and solid tumor malignancies, including melanoma that were treated with alpha interferon, methotrexate, cisplatin, interleukin 2, and vemurafenib [14, 31]. Historically, augmentation of the patient’s immune response with intralesional bacilli Calmette-Guerin (BCG) for melanoma therapy appeared promising with clinical benefits in some patients [32]. BCG therapy associated activation of melanoma specific and nonspecific immune response induced the development of granulomata. Serial biopsies taken of lesions at early (24 h), middle (2-3 weeks), and late (> 3 weeks to ≤2 months) time points after BCG administration, exhibited distinct histomorphology [32]. Early lesions had inflammatory response with polymorphonuclear leukocytes, lymphocytes, and mononuclear cells towards the periphery with some disruption of melanoma cells and pigment release. Examination of lesions taken during the middle course of BCG therapy, showed early granuloma formation with macrophages, lymphocytes, and giant cells, and late lesions exhibited organized, well form non-caseating granulomata [32]. Parallel with BCG therapy, CPIs attempt to restore patient’s immune function by blocking inhibitory signals with anti-CTLA-4 or anti-PD-1/PD-L1. Similar granulomatous/sarcoid-like reactions are being now being recognized with the current class of CPIs. Interestingly, in our review of granulomatous/sarcoid-like lesions associated with checkpoint inhibitors, this finding occurred in more than three quarters of the patients under therapy for metastatic melanoma. Melanomas are highly immunogenic and the neoantigen landscape in melanoma cells poses a significant impact on anti-tumor activity of T-cells and response to immune checkpoint therapy [33, 34]. Activation of cytotoxic T-cells and enhanced killing of melanoma cells after treatment with CPIs may possibly expose additional neoantigens presented by antigen presenting cells that promote Th1 response and cytokine milieu favorable to develop granulomatous/sarcoid-like lesions during CPI therapy.

Various types of dermatologic toxicities to immune checkpoint therapy can be grouped as inflammatory processes, reactions that target keratinocytes, and affect melanocytes. Immune-mediated reactions that target melanocytes may manifest as vitiligo and/or regression of nevi have been associated with favorable therapeutic response to immune checkpoint therapy [5, 35]. The development of granulomatous/sarcoid-like lesions associated with CPIs appear to be another irAE associated with a favorable therapeutic response in a subset of patients treated with immune checkpoint antibodies (Table 1).

The immunopathogenesis of sarcoidal granulomata involve the interaction of monocyte-derived histiocytes and CD4+ Th1 cells [12]. An array of cytokines and chemokines is involved in the development of sarcoidosis, although Tumor Necrosis Factor-α (TNF-α) is thought to be central to the formation and maintenance of these “sarcoidal” granulomata [12]. Thus, monoclonal antibodies to TNF-α (i.e., infliximab and adalimumab) have been successful in the treatment of sarcoidosis [36, 37]. Intriguingly, some patients who received anti-TNF-α therapy for the management of their inflammatory bowel disease, psoriasis, arthritis, or sarcoidosis developed paradoxical sarcoidosis-like reactions to therapy [29, 38,39,40,41]. Investigators have suggested that anti-TNF-α therapy may impair the regulatory role of TNF-α on autoreactive T cells, resulting in a cytokine imbalance and promoting Th1 immune response [42].

There are competing paradigms in the immunopathogenesis of sarcoidosis that either involve a hypoactive or hyperactive immune response [9]. Patients who develop sarcoidosis unrelated to immune checkpoint therapy are thought to have a hypoactive immune response with decreased T-cell proliferation and PD-1 up-regulation [43]. In contrast, those who develop sarcoidosis related to immune checkpoint blockade would support a hyperactive immune response with increased T-cell proliferation and inhibition of PD-1 signaling [9]. The extent of the disruption of mediators in homeostasis and cytokine imbalance may promote the development of granulomatous/sarcoid-like lesions associated with CPIs that exhibits granulomatous panniculitis features with multinucleated giant cells to “sarcoidal” granulomata [11].

There are variety of terminologies utilized in the literature (Table 1) that describe manifestation of granulomatous/sarcoid-like lesions associated with CPIs and include: “sarcoidosis”, “cutaneous sarcoidosis”, “sarcoidosis-like syndrome”, “sarcoid-like granulomatosis” and among others. To avoid confusion with disease of systemic sarcoidosis, unrelated to CPIs, we suggest the term “granulomatous/sarcoid-like lesions associated with CPIs” involving the organ type (e.g. skin, lungs, etc). This term will encompass all granulomatous reactions (e.g. granulomatous panninculitis) that occur during CPI therapy as well as lesions with granulomas that morphologically appear “sarcoidal”. This terminology will also incorporate previously described reports in the literature of “sarcoid” granulomas from CPI therapy.

Sarcoidosis is a systemic disease and remains a diagnosis of exclusion. A presumptive diagnosis of sarcoidosis may be made on the basis of clinical and radiographic features [44]. Bilateral hilar lymphadenopathy is the most common finding and the patients may be asymptomatic or may present with nonspecific skin lesions of erythema nodosum–like panniculitis [14]. Alternatively, the patient may present with a triad of uveitis, parotiditis, and fever or with abnormal gallium imaging with increased uptake in the parotid and lacrimal gland and right paratracheal and bilateral hilar uptake [44].

The development of granulomatous/sarcoid-like lesions associated with CPIs is an immune-mediated toxicity that may clinically and radiographically mimic disease recurrence and/or progression. Recognition of this type of toxicity is important for appropriate management and possible measurement of therapeutic response in a subset of patients that manifest this type of immune-mediated adverse event.

Abbreviations

CPIs:

Checkpoint inhibitors

CT:

Computed tomography

CTLA-4:

cytotoxic T-lymphocyte–associated protein-4

FDG:

Fludeoxyglucose

irAE:

Immune-related adverse events

LAD:

Lymphadenopathy

PD-1:

Programmed cell death protein 1

PET/CT:

Positron emission tomography/computed tomography

Th:

T helper

TNF-α:

Tumor Necrosis Factor-α

References

  1. Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711–23.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  2. Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015;372(4):320–30.

    CAS  Article  PubMed  Google Scholar 

  3. Ciccarese C, Alfieri S, Santoni M, Santini D, Brunelli M, Bergamini C, et al. New toxicity profile for novel immunotherapy agents: focus on immune-checkpoint inhibitors. Expert Opin Drug Metab Toxicol. 2016;12(1):57–75.

    CAS  Article  PubMed  Google Scholar 

  4. Jour G, Glitza IC, Ellis RM, Torres-Cabala CA, Tetzlaff MT, Li JY, et al. Autoimmune dermatologic toxicities from immune checkpoint blockade with anti-PD-1 antibody therapy: a report on bullous skin eruptions. J Cutan Pathol. 2016;43(8):688–96.

    Article  PubMed  Google Scholar 

  5. Curry JL, Tetzlaff MT, Nagarajan P, Drucker C, Diab A, Hymes SR, et al. Diverse types of dermatologic toxicities from immune checkpoint blockade therapy. J Cutan Pathol. 2017;44(2):158–76.

    Article  PubMed  Google Scholar 

  6. Tetzlaff MT, Nagarajan P, Chon S, Huen A, Diab A, Omar P, et al. Lichenoid dermatologic toxicity from immune checkpoint blockade therapy: a detailed examination of the Clinicopathologic features. Amer J Dermatopathol. 2017;39(2):121–29.

    Article  Google Scholar 

  7. Andersen R, Norgaard P, Al-Jailawi MK, Svane IM. Late development of splenic sarcoidosis-like lesions in a patient with metastatic melanoma and long-lasting clinical response to ipilimumab. Oncoimmunology. 2014;3(8):e954506.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Suozzi KC, Stahl M, Ko CJ, Chiang A, Gettinger SN, Siegel MD, et al. Immune-related sarcoidosis observed in combination ipilimumab and nivolumab therapy. JAAD Case Rep. 2016;2(3):264–68.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Birnbaum MR, Ma MW, Fleisig S, Packer S, Amin BD, Jacobson M, et al. Nivolumab-related cutaneous sarcoidosis in a patient with lung adenocarcinoma. JAAD Case Rep. 2017;3(3):208–11.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Burillo-Martinez S, Morales-Raya C, Prieto-Barrios M, Rodriguez-Peralto JL, Ortiz-Romero PL. Pembrolizumab-induced extensive Panniculitis and nevus regression: two novel Cutaneous manifestations of the post-immunotherapy Granulomatous reactions Spectrum. JAMA Dermatol. 2017;153(7):721–22.

    Article  PubMed  Google Scholar 

  11. Tetzlaff MT, Jazaeri AA, Torres-Cabala CA, Rao BK, Landone G, Nagarajan P, Choksi AN, Chen L, Uemura M, Aung PP et al: Erythema nodosum-like panniculitis mimicking disease recurrence: A novel toxicity from immune checkpoint blockade therapy. Report of two patients. J Cutan Pathol. 2017;44(12):1080-86.

  12. Timmermans WM, van Laar JA, van Hagen PM, van Zelm MC. Immunopathogenesis of granulomas in chronic autoinflammatory diseases. Clin Transl Immunology. 2016;5(12):e118.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Valeyre D, Prasse A, Nunes H, Uzunhan Y, Brillet PY, Muller-Quernheim J. Sarcoidosis. Lancet. 2014;383(9923):1155–67.

    Article  PubMed  Google Scholar 

  14. Beutler BD, Cohen PR. Sarcoidosis in melanoma patients: case report and literature review. Cancer. 2015;7(2):1005–21.

    Article  Google Scholar 

  15. Firwana B, Ravilla R, Raval M, Hutchins L, Mahmoud F. Sarcoidosis-like syndrome and lymphadenopathy due to checkpoint inhibitors. J Oncol Pharm Pract. 2017;23(8):620–24.

    CAS  Article  PubMed  Google Scholar 

  16. Eckert A, Schoeffler A, Dalle S, Phan A, Kiakouama L, Thomas L. Anti-CTLA4 monoclonal antibody induced sarcoidosis in a metastatic melanoma patient. Dermatology. 2009;218(1):69–70.

    CAS  Article  PubMed  Google Scholar 

  17. Seve P, Schott AM, Pavic M, Broussolle C, Gilis L, Thomas L. Sarcoidosis and melanoma: a referral center study of 1,199 cases. Dermatology. 2009;219(1):25–31.

    Article  PubMed  Google Scholar 

  18. Vogel WV, Guislain A, Kvistborg P, Schumacher TN, Haanen JB, Blank CU. Ipilimumab-induced sarcoidosis in a patient with metastatic melanoma undergoing complete remission. J Clin Oncol. 2012;30(2):e7–e10.

    Article  PubMed  Google Scholar 

  19. Wilgenhof S, Morlion V, Seghers AC, Du Four S, Vanderlinden E, Hanon S, et al. Sarcoidosis in a patient with metastatic melanoma sequentially treated with anti-CTLA-4 monoclonal antibody and selective BRAF inhibitor. Anticancer Res. 2012;32(4):1355–59.

    CAS  PubMed  Google Scholar 

  20. Berthod G, Lazor R, Letovanec I, Romano E, Noirez L, Mazza Stalder J, et al. Pulmonary sarcoid-like granulomatosis induced by ipilimumab. J Clin Oncol. 2012;30(17):e156–59.

    Article  PubMed  Google Scholar 

  21. Tissot C, Carsin A, Freymond N, Pacheco Y, Devouassoux G. Sarcoidosis complicating anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody biotherapy. Eur Respir J. 2013;41(1):246–47.

    Article  PubMed  Google Scholar 

  22. Reule RB, North JP. Cutaneous and pulmonary sarcoidosis-like reaction associated with ipilimumab. J Am Acad Dermatol. 2013;69(5):e272–73.

    Article  PubMed  Google Scholar 

  23. Murphy KP, Kennedy MP, Barry JE, O'Regan KN, Power DG. New-onset mediastinal and central nervous system sarcoidosis in a patient with metastatic melanoma undergoing CTLA4 monoclonal antibody treatment. Oncol Res Treat. 2014;37(6):351–53.

    CAS  Article  PubMed  Google Scholar 

  24. Toumeh A, Sakhi R, Shah S, Arudra SK, De Las Casas LE, Skeel RT. Ipilimumab-induced Granulomatous disease occurring simultaneously with disease progression in a patient with metastatic melanoma. Am J Ther. 2016;23(4):e1068–71.

    Article  PubMed  Google Scholar 

  25. van den Eertwegh AJ, Versluis J, van den Berg HP, Santegoets SJ, van Moorselaar RJ, van der Sluis TM, et al. Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial. Lancet Oncol. 2012;13(5):509–17.

    CAS  Article  PubMed  Google Scholar 

  26. Montaudie H, Pradelli J, Passeron T, Lacour JP, Leroy S. Pulmonary sarcoid-like granulomatosis induced by nivolumab. Br J Dermatol. 2017;176(4):1060–63.

    CAS  Article  PubMed  Google Scholar 

  27. Danlos FX, Pages C, Baroudjian B, Vercellino L, Battistella M, Mimoun M, et al. Nivolumab-induced Sarcoid-like Granulomatous reaction in a patient with advanced melanoma. Chest. 2016;149(5):e133–36.

    Article  PubMed  Google Scholar 

  28. Cotliar J, Querfeld C, Boswell WJ, Raja N, Raz D, Chen R. Pembrolizumab-associated sarcoidosis. JAAD Case Rep. 2016;2(4):290–93.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Swu P, et al. Safety and activity of anti-PD-L1 antibody in patients with advacned cancer. N Engl J Med. 2012;366(26):2455–65.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  30. Tana C, Giamberardino MA, Di Gioacchino M, Mezzetti A, Schiavone C. Immunopathogenesis of sarcoidosis and risk of malignancy: a lost truth? Int J Immunopathol Pharmacol. 2013;26(2):305–13.

    CAS  Article  PubMed  Google Scholar 

  31. Cohen PR, Kurzrock R. Sarcoidosis and malignancy. Clin Dermatol. 2007;25(3):326–33.

    Article  PubMed  Google Scholar 

  32. Lieberman R, Wybran J, Epstein W. The immunologic and histopathologic changes of BCG-mediated tumor regression in patients with malignant melanoma. Cancer. 1975;35(3):756–77.

    CAS  Article  PubMed  Google Scholar 

  33. Verdegaal EM, de Miranda NF, Visser M, Harryvan T, van Buuren MM, Andersen RS, Hadrup SR, et al. Neoantigen landscape dynamics during human melanoma-T cell interactions. Nature. 2016;536(7614):91–95.

    CAS  Article  PubMed  Google Scholar 

  34. Kristensen VN. The Antigenicity of the tumor cell - context matters. N Engl J Med. 2017;376(5):491–93.

    Article  PubMed  Google Scholar 

  35. Mauzo SH, Tetzlaff MT, Nelson K, Amaria R, Patel S, Aung PP, Nagarajan P et al. Regressed melanocytic nevi secondary to pembrolizumab therapy: an emerging melanocytic dermatologic effect from immune checkpoint antibody blockade. Int J Dermatol. 2017 (Epub ahead of print).

  36. Doty JD, Mazur JE, Judson MA. Treatment of sarcoidosis with infliximab. Chest. 2005;127(3):1064–71.

    CAS  Article  PubMed  Google Scholar 

  37. Patel SR. Systemic sarcoidosis with bone marrow involvement responding to therapy with adalimumab: a case report. J Med Case Reports. 2009;3:8573.

    Article  PubMed Central  Google Scholar 

  38. Decock A, Van Assche G, Vermeire S, Wuyts W, Ferrante M. Sarcoidosis-like lesions: another paradoxical reaction to anti-TNF therapy? J Crohns Colitis. 2017;11(3):378–83.

    PubMed  Google Scholar 

  39. Santos G, Sousa LE, Joao AM. Exacerbation of recalcitrant cutaneous sarcoidosis with adalimumab--a paradoxical effect? A case report. An Bras Dermatol. 2013;88(6 Suppl 1):26–28.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Clementine RR, Lyman J, Zakem J, Mallepalli J, Lindsey S, Quinet R. Tumor necrosis factor-alpha antagonist-induced sarcoidosis. J Clin Rheumatol. 2010;16(6):274–79.

    Article  PubMed  Google Scholar 

  41. Marcella S, Welsh B, Foley P. Development of sarcoidosis during adalimumab therapy for chronic plaque psoriasis. Australas J Dermatol. 2011;52(3):e8–11.

    Article  PubMed  Google Scholar 

  42. Massara A, Cavazzini L, La Corte R, Trotta F. Sarcoidosis appearing during anti-tumor necrosis factor alpha therapy: a new “class effect” paradoxical phenomenon. Two case reports and literature review. Semin Arthritis Rheum. 2010;39(4):313–19.

    CAS  Article  PubMed  Google Scholar 

  43. Celada LJ, Rotsinger JE, Young A, Shaginurova G, Shelton D, Hawkins C, et al. Programmed Death-1 inhibition of Phosphatidylinositol 3-Kinase/AKT/mechanistic target of Rapamycin signaling impairs Sarcoidosis CD4(+) T cell proliferation. Am J Respir Cell Mol Biol. 2017;56(1):74–82.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  44. Baughman RP, Culver DA, Judson MA. A concise review of pulmonary sarcoidosis. Am J Respir Crit Care Med. 2011;183(5):573–81.

    CAS  Article  PubMed  Google Scholar 

Download references

Acknowledgements

We acknowledge Tamara Locke in the Department of Scientific Publications at MD Anderson Cancer Center for her editorial review.

Funding

None

Availability of data and materials

Not applicable

Author information

Authors and Affiliations

  1. Department of Pathology, Section of Dermatopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Michael T. Tetzlaff, Priyadharsini Nagarajan, Carlos A. Torres-Cabala, Victor G. Prieto & Jonathan L. Curry

  2. Department of Translational and Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Michael T. Tetzlaff

  3. Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Kelly C. Nelson, Carlos A. Torres-Cabala, Victor G. Prieto & Jonathan L. Curry

  4. Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Adi Diab & Rodabe N. Amaria

  5. Department of Pathology, Section of Cytopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Gregg A. Staerkel

  6. Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Beth A. Chasen

  7. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Jennifer A. Wargo

Authors
  1. Michael T. Tetzlaff
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kelly C. Nelson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Adi Diab
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gregg A. Staerkel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Priyadharsini Nagarajan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Carlos A. Torres-Cabala
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Beth A. Chasen
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jennifer A. Wargo
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Victor G. Prieto
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Rodabe N. Amaria
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Jonathan L. Curry
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

MTT and JLC wrote the manuscript; KN, PN, and RA provided cases; BC provided radiographic findings; all authors reviewed, edited, and approved of the final manuscript.

Corresponding author

Correspondence to Jonathan L. Curry.

Ethics declarations

Ethics approval and consent to participate

The study was approved by the Institutional Review Board at The University of Texas MD Anderson Cancer Center.

Consent for publication

Not applicable

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Tetzlaff, M.T., Nelson, K.C., Diab, A. et al. Granulomatous/sarcoid-like lesions associated with checkpoint inhibitors: a marker of therapy response in a subset of melanoma patients. j. immunotherapy cancer 6, 14 (2018). https://doi.org/10.1186/s40425-018-0323-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s40425-018-0323-0

Keywords

  • Checkpoint Inhibitors (CPIs)
  • Immune Checkpoint Therapy
  • Dermatologic Toxicity
  • Pembrolizumab Therapy
  • Positron Emission tomography-CT (PET/CT)